Research progress in new biomarkers of pediatric acute kidney injury

doi:10.3969/j.issn.1673-8640.2018.09.018

Abstract

Abstract:

Acute kidney injury （AKI） is a common critical disease with high morbidity and mortality in hospitalized children. AKI has fast progress,and early diagnosis and risk prediction can assist clinical physicians in starting timely therapy and could effectively improve patients' prognosis. Traditional biomarker,serum creatinine,is related with renal function,but it can not timely reflect kidney injury. Recently,many new potential biomarkers have been widely investigated,such as neutrophil gelatinase-associated lipocalin（NGAL）,kidney injury molecule-1（KIM-1）,insulin-like growth factor-binding protein 7（IGFBP7） and tissue inhibitor of metalloproteinase-2（TIMP-2）. Children have their own unique growth and development rules. These biomarkers are at different baseline levels in different ages. This review summarizes the pathophysiological basis of these new AKI biomarkers,the application in the early diagnosis,risk stratification and prognostic evaluation of pediatric AKI and the difference for clinical performance compared with adult patients.

Key words: Neutrophil gelatinase-associated lipocalin, Kidney injury molecule-1, Insulin-like growth factor-binding protein 7, Tissue inhibitor of metalloproteinase-2, Acute kidney injury, Child

CLC Number:

R446.1

TIAN Xiaoyi, SHEN Ying, SONG Wenqi. Research progress in new biomarkers of pediatric acute kidney injury[J]. Laboratory Medicine, 2018, 33(9): 850-856.

Figures/Tables 1

References 39

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类别	生物标志物	部位
功能性生物标志物	胱抑素C	肾小球
	视黄醇结合蛋白	近曲小管
肾小管损伤相关酶	NAG	近曲小管
上调蛋白类	KIM-1	近曲小管
	L-FABP	近曲小管
	NGAL	远曲小管、髓袢升支粗段、集合管
	IL-18	肾小管上皮细胞和集合管
	IGFBP7	肾小管上皮细胞
	TIMP-2	肾小管上皮细胞
	富半胱氨酸肝素结合蛋白61
	丛生蛋白	近曲小管和远曲小管
	Na⁺/H⁺交换器同工酶3	近曲小管
	胎球蛋白A	近曲小管

类别	生物标志物	部位
功能性生物标志物	胱抑素C	肾小球
	视黄醇结合蛋白	近曲小管
肾小管损伤相关酶	NAG	近曲小管
上调蛋白类	KIM-1	近曲小管
	L-FABP	近曲小管
	NGAL	远曲小管、髓袢升支粗段、集合管
	IL-18	肾小管上皮细胞和集合管
	IGFBP7	肾小管上皮细胞
	TIMP-2	肾小管上皮细胞
	富半胱氨酸肝素结合蛋白61
	丛生蛋白	近曲小管和远曲小管
	Na⁺/H⁺交换器同工酶3	近曲小管
	胎球蛋白A	近曲小管