An investigation on the reference range of glycosylated hemoglobin A1c in neonatal umbilical cord blood

doi:10.3969/j.issn.1673-8640.2014.11.004

Abstract

Abstract:

Objective　To investigate the reference range of neonatal glycosylated hemoglobin A_1c (HbA_1c). Methods　A total of 1 003 healthy infants were enrolled, and their blood samples from umbilical cord were collected. HbA_1c levels were determined by affinity chromatography, and were calculated according to P₂_.₅-P_97.5. Results　The HbA_1c levels showed a positive skewness distribution. The median of HbA_1c levels was 3.80%. The 95% reference ranges for HbA_1c levels were 3.46%- 4.25%. There was no significant influence of infants' sex and delivery ways on HbA_1c levels (P>0.05). There was a positive correlation between HbA_1c levels and the blood glucose of infants (r=0.118, P=0.028) and no correlation with the weight of infants (r=0.064, P=0.168). Conclusions　HbA_1c levels can help for monitoring the blood glucose of infants, and the reference range has an important significance in clinic.

Key words: Neonatal umbilical cord blood, Glycosylated hemoglobin A1c, Reference range, Investigation

CLC Number:

R446.1

ZHANG Li, YU Jing, WANG Jieyun, GU Qin, LI Haichuan, HOU Yaping, GONG Bo. An investigation on the reference range of glycosylated hemoglobin A_1c in neonatal umbilical cord blood[J]. , 2014, 29(11): 1094-1096.

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An investigation on the reference range of glycosylated hemoglobin A_1c in neonatal umbilical cord blood

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