Abstract: [Abstract] Objective To study the value of fibronectin (Fn ) among healthy children (aged 0-14 years) in native,and to establish the children's medical reference range. Methods The 353 children aged 0-14 years whose liver, kidney, heart and lung functions were normal were selected as subjects,in which there were 229 males and 124 females. The sample was divided into three groups: 0-1 years,1-3 years and 4-14 years. Fn was detected in the ABBOTT Aeroset full-automatic biochemical Analyzer ( American company Abbott ) with immune turbidimetry principle and with biochemical reagents producted by Shanghai North biochemical reagents company,and the detection results were processed according to CLSIC28-A2 (clinical laboratory reference ranges are defined and confirmed-2nd Edition). Results The fibronectin reference range in healthy children was 122.8-250.2 μg/ml, 125.5-270.7 μg/ml, 128.9-279.4 μg/ml in male and 125.2-289.5μg/ml,130.3-280.0μg/ml, 132.6-262.1μg/ml in female. Conclusions The laboratory is necessary to establish its own reference range according to the CLSIC28-A2 documents,in order to provide reference to different clinical departments.

Key words: Fibronectin, Medical reference range, Child