Abstract:

Objective　To investigate the distribution and drug resistance of pathogenic bacteria from blood culture of children in Nanjing during recent 3 years. Methods　The distribution and drug resistance of pathogenic bacteria from blood culture of children in Nanjing Children′s Hospital from January 2009 to December 2011 were analyzed retrospectively. Results　Totally 2 489 isolates of bacteria were collected from 14 232 blood culture samples. The isolation rate was 17.5%. A total of 2 082 isolates of Gram positive bacteria accounted for 83.6%. Gram negative bacteria and fungi accounted for 13.8% (344 isolates) and 2.6%(63 isolates), respectively. The main of Gram positive bacteria was coagulase negative Staphylococcus(CNS), and Escherichia coli was the most part of Gram negative bacteria. Gram positive bacteria were sensitive to vancomycin, ciprofloxacin and rifampicin and resistant to penicillin seriously. Gram negative bacteria were sensitive to imipenem,amikacin and cefoperazone-sulbactam. Conclusions　Gram positive bacteria are the most frequently pathogenic bacteria from blood culture of children in Nanjing. Drug resistance is serious in these isolates. We should recognize the results of drug sensitivity tests and the indication of pathogenic bacteria to use antibiotics reasonably.

Key words: Blood culture, Pathogenic bacterium, Drug resistance, Child