检验医学 ›› 2021, Vol. 36 ›› Issue (12): 1283-1286.DOI: 10.3969/j.issn.1673-8640.2021.012.018
赵小霞
收稿日期:2020-10-03
出版日期:2021-12-30
发布日期:2021-12-29
作者简介:赵小霞,女,1979年生,博士,副主任技师,主要从事临床血栓与止血检测工作。
ZHAO Xiaoxia
Received:2020-10-03
Online:2021-12-30
Published:2021-12-29
摘要:
线粒体对无细胞核的血小板的生理功能及生物活性具有重要作用。文章对线粒体在血小板能量代谢和三磷酸腺苷(ATP)的产生、活化、2周凋亡和系统性疾病中的病理生理作用进行综述,以期为进一步的学术研究和临床治疗提供参考。
中图分类号:
赵小霞. 血小板线粒体功能研究进展[J]. 检验医学, 2021, 36(12): 1283-1286.
ZHAO Xiaoxia. Research progress of mitochondria in platelets[J]. Laboratory Medicine, 2021, 36(12): 1283-1286.
| [1] |
HOLINSTAT M. Normal platelet function[J]. Cancer Metas Rev, 2017, 36(2):195-198.
DOI URL |
| [2] |
XIA L, ZENG Z, TANG W H. The role of platelet microparticle associated microRNAs in cellular crosstalk[J]. Front Cardiovasc Med, 2018, 5:29.
DOI URL |
| [3] |
DUCHEZ A C, BOUDREAU L H, NAIKA G S, et al. Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA[J]. Proc Natl Acad Sci U S A, 2015, 112(27):E3564-E3573.
DOI URL |
| [4] |
KÜHLBRANDT W. Structure and function of mitochondrial membrane protein complexes[J]. BMC Biol, 2015, 13:89.
DOI URL |
| [5] |
KHOLMUKHAMEDOV A, JOBE S. Platelet respiration[J]. Blood Adv, 2019, 3(4):599-602.
DOI URL |
| [6] |
BAATEN C C F M J, MOENEN F C J I, HENSKENS Y M C, et al. Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy[J]. Haematologica, 2018, 103(9):1557-1567.
DOI URL |
| [7] | DAVIZON-CASTILLO P, MCMAHON B, AGUILA S, et al. TNF-alpha-driven inflflammation and mitochondrial dysfunction defifine the platelet hyperreactivity of aging[J]. Blood, 2019, 134(9):727-740. |
| [8] |
GARCIA-SOUZA L F, OLIVEIRA M F. Mitochondria:biological roles in platelet physiology and pathology[J]. Int J Biochem Cell Biol, 2014, 50:156-160.
DOI URL |
| [9] |
VAN DER LAAN M, MEINECKE M, DUDEK J, et al. Motor-free mitochondrial presequence translocase drives membrane integration of preproteins[J]. Nat Cell Biol, 2007, 9(10):1152-1159.
DOI URL |
| [10] |
BACCARELLI A A, BYUN H M. Platelet mitochondrial DNA methylation:a potential new marker of cardiovascular disease[J]. Clin Epigenetics, 2015, 7(1):44.
DOI URL |
| [11] |
CHOO H J, SAAFIR T B, MKUMBA L, et al. Mitochondrial calcium and reactive oxygen species regulate agonist-initiated platelet phosphatidylserine exposure[J]. Arterioscler Thromb Vasc Biol, 2012, 32(12):2946-2955.
DOI URL |
| [12] |
FIGUEIRA T R, BARROS M H, CAMARGO A A, et al. Mitochondria as a source of reactive oxygen and nitrogen species:from molecular mechanisms to human health[J]. Antioxid Redox Signal, 2013, 18(16):2029-2074.
DOI URL |
| [13] |
GYULKHANDANYAN A V, MUTLU A, FREEDMAN J, et al. Markers of platelet apoptosis:methodology and applications[J]. J Thromb Thrombolysis, 2012, 33(4):397-411.
DOI URL |
| [14] |
DEBRINCAT M A, PLEINES I, LEBOIS M, et al. BCL-2 is dispensable for thrombopoiesis and platelet survival[J]. Cell Death Dis, 2015, 6(4):e1721.
DOI URL |
| [15] |
FIDLER T P, CAMPBELL R A, FUNARI T, et al. Deletion of GLUT1 and GLUT3 reveals multiple roles for glucose metabolism in platelet and megakaryocyte function[J]. Cell Rep, 2017, 20(4):881-894.
DOI URL |
| [16] |
BHATLEKAR S, BASAK I, EDELSTEIN L C, et al. Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood[J]. Haematologica, 2019, 104(10):2075-2083.
DOI URL |
| [17] |
LANNAN K L, PHIPPS R P, WHITE R J. Thrombosis,platelets,microparticles and PAH:more than a clot[J]. Drug Discov Today, 2014, 19(8):1230-1235.
DOI URL |
| [18] |
SONG S, PURSELL Z F, COPELAND W C, et al. DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fifidelity[J]. Proc Natl Acad Sci U S A, 2005, 102(14):4990-4995.
DOI URL |
| [19] |
LINDQVIST D, WOLKOWITZ O M, PICARD M, et al. Circulating cell-free mitochondrial DNA,but not leukocyte mitochondrial DNA copy number,is elevated in major depressive disorder[J]. Neuropsychopharmacology, 2018, 43(7):1557-1564.
DOI URL |
| [20] |
SHOKOLENKO I N, WILSON G L, ALEXEYEV M F. Aging:a mitochondrial DNA perspective,critical analysis and an update[J]. World J Exp Med, 2014, 4(4):46-57.
DOI URL |
| [21] | KOÇER A, YAMAN A, NIFTALIYEV E, et al. Assessment of platelet indices in patients with neurodegenerative diseases:mean platelet volume was increased in patients with Parkinson's disease[J]. Curr Gerontol Geriatr Res, 2013, 2013:986254. |
| [22] |
WILLOUGHBY S, HOLMES A, LOSCALZO J. Platelets and cardiovascular disease[J]. Eur J Cardiovasc Nurs, 2002, 1(4):273-288.
DOI URL |
| [23] |
SANTILLI F, SIMEONE P, LIANI R, et al. Platelets and diabetes mellitus[J]. Prostaglandins Other Lipid Mediat, 2015, 120:28-39.
DOI URL |
| [24] |
DEWITTE A, LEPREUX S, VILLENEUVE J, et al. Blood platelets and sepsis pathophysiology:a new therapeutic prospect in critically [corrected] ill patients?[J]. Ann Intensive Care, 2017, 7(1):115.
DOI URL |
| [25] |
TANG W H, STITHAM J, JIN Y, et al. Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction,and damage in diabetic platelets[J]. Circulation, 2014, 129(15):1598-1609.
DOI URL |
| [26] | 余司文, 武强, 王艳华, 等. 2型糖尿病患者血小板参数及血小板表面相关膜糖蛋白和线粒体膜电位表达的临床意义[J]. 贵州医科大学学报, 2019, 44(9):1105-1108. |
| [27] | TANG W H, MARTIN K A, HWA J. Aldose reductase,oxidative stress,and diabetic mellitus[J]. Front Pharmacol, 2012, 3:87. |
| [28] |
XIN G, WEI Z, JI C, et al. Metformin uniquely prevents thrombosis by inhibiting platelet activation and mtDNA release[J]. Sci Rep, 2016, 6:36222.
DOI URL |
| [29] |
VEITINGER M, VARGA B, GUTERRES S B, et al. Platelets,a reliable source for peripheral Alzheimer's disease biomarkers?[J]. Acta Neuropathol Commun, 2014, 2:65.
DOI URL |
| [30] |
BEHARI M, SHRIVASTAVA M. Role of platelets in neurodegenerative diseases:a universal pathophysiology[J]. Int J Neurosci, 2013, 123(5):287-299.
DOI URL |
| [31] |
VALLA J, BERNDT J D, GONZALEZ-LIMA F. Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients:superfificial laminar cytochrome oxidase associated with disease duration[J]. J Neurosci, 2001, 21(13):4923-4930.
DOI URL |
| [32] |
ZHARIKOV S, SHIVA S. Platelet mitochondrial function:from regulation of thrombosis to biomarker of disease[J]. Biochem Soc Trans, 2013, 41(1):118-123.
DOI URL |
| [33] | DIAS V, JUNN E, MOURADIAN M M. The role of oxidative stress in Parkinson's disease[J]. J Parkinsons Dis, 2013, 3(4):461-491. |
| [34] | LEE S H, LEE S, DU J, et al. Mitochondrial MsrB2 serves as a switch and transducer for mitophagy[J]. EMBO Mol Med, 2019, 11(8):e10409. |
| [35] | ALI R A, WUESCHER L M, WORTH R G. Platelets:essential components of the immune system[J]. Curr Trends Immunol, 2015, 16:65-78. |
| [36] | 孙旭影, 吴晓梅. 血小板在脓毒症中致多器官衰竭的研究进展[J]. 临床肺科杂志, 2018, 23(10):1915-1917. |
| [37] |
CLAUSHUIS T A M, VAN VUGHT L A, SCICLUNA B P, et al. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients[J]. Blood, 2016, 127(24):3062-3072.
DOI URL |
| [38] | 袁静静, 方晨, 梅俏. 炎症性肠病患者血小板线粒体DNA拷贝数改变的临床意义[J]. 中华消化杂志, 2019, 39(5):342-345. |
| [39] |
GYULKHANDANYAN A V, MUTLU A, FREEDMAN J, et al. Markers of platelet apoptosis:methodology and applications[J]. J Thromb Thrombolysis, 2012, 33(4):397-411.
DOI URL |
| [1] | 张辉, 袁靖雯, 张驰. 武汉地区成人荧光法血小板计数和血小板相关参数参考区间调查[J]. 检验医学, 2025, 40(9): 892-896. |
| [2] | 陈文丽, 金成, 周露露, 徐卫益. MicroR在指导血小板计数复检中的应用[J]. 检验医学, 2025, 40(9): 897-900. |
| [3] | 刘慧芳, 罗建江. 哮喘患者L-Arg/ADMA比值与线粒体功能的关系[J]. 检验医学, 2025, 40(8): 725-730. |
| [4] | 赵君, 王鹏. 基于血常规指标和NLR、PLR、MLR诊断儿童腺病毒感染[J]. 检验医学, 2025, 40(8): 817-820. |
| [5] | 林斐然, 欧元祝, 虞啸炫, 葛丹红, 龚敬凯, 赵品琪, 王雯琴. 不同品牌线粒体天门冬氨酸氨基转移酶试剂检测结果一致性分析[J]. 检验医学, 2025, 40(7): 703-707. |
| [6] | 姜风英, 姜云, 米瑞, 钱希铭, 王秋波. 老年糖尿病足溃疡患者血小板和凝血功能指标变化及其临床意义[J]. 检验医学, 2025, 40(7): 708-712. |
| [7] | 李越, 李莉, 杨晨. 不同流产次数复发性流产患者血小板聚集率、D-二聚体水平变化分析[J]. 检验医学, 2025, 40(3): 294-298. |
| [8] | 周嘉宽, 郭平, 蔡祺, 杨铭康, 黄之玺, 薛伊伦, 华任翔, 林瀚, 李佳明, 王剑飚. 外周血口形红细胞增多伴巨大血小板患者分子流行病学分析[J]. 检验医学, 2025, 40(2): 171-177. |
| [9] | 李博, 夏永泉, 沈萍, 夏茂, 曾佳威. 肿瘤相关血栓的发生机制[J]. 检验医学, 2025, 40(2): 192-196. |
| [10] | 李松, 向旭. 老年发热伴血小板减少综合征患者预后危险因素及其临床价值[J]. 检验医学, 2025, 40(12): 1183-1189. |
| [11] | 季雄娟, 陆胜, 周卫平. 血小板抗体形成影响因素分析[J]. 检验医学, 2025, 40(11): 1102-1104. |
| [12] | 娄展, 彭涛, 刘星亮, 岳秉宏, 李燃, 智永怡. 血管性帕金森综合征患者线粒体自噬信号通路PINK1/Parkin表达及其与神经功能的关系[J]. 检验医学, 2024, 39(6): 542-547. |
| [13] | 代尧, 黎佳慧, 徐秀红. 基于肺炎支原体DNA和外周血炎症指标构建儿童肺炎支原体肺炎预后评估模型[J]. 检验医学, 2024, 39(6): 568-572. |
| [14] | 熊天慧, 柴可宁, 夏薇, 曲林琳. 利伐沙班所致PLT计数和功能变化研究进展[J]. 检验医学, 2024, 39(5): 504-509. |
| [15] | 陆文苑, 徐静雅, 丁宁. MPV、DD诊断急性脑梗死患者不同梗死部位病变的价值[J]. 检验医学, 2024, 39(2): 171-175. |
| 阅读次数 | ||||||
|
全文 |
|
|||||
|
摘要 |
|
|||||