关键词: 厌氧菌, 耐药性, 原发感染疾病, 败血症

Abstract:

Objective To study the pathogen distribution and drug resistance of anaerobic bacteria for bloodstream infection,to investigate primary infectious diseases,and to provide a reference on controlling the occurrence of anaerobic bacterium bloodstream infection. Methods BacT/ALERT 3D automatic blood culture system was used to perform blood culturing,and ATB expression automated analysis system was used for bacterial identification and drug susceptibility. Results Among 63 isolates of anaerobic bacteria,Clostridium perfringens accounted for 31.7%,Bacteroides fragili accounted for 25.4%,and Fusobacterium fragiformisaccounted for 11.1%. The drug resistance rates to metronidazole,carbapenem,chloramphenicol and enzyme inhibitors were all <10.0%,and the drug resistance rate to metronidazole was <2.0%. The drug resistance rates to penicillin and clindamycin were >30.0%. Gram-positive anaerobic bacteria were susceptible to cefoxitin and cefotetan. The drug resistance rates of Gram-negative anaerobic bacteria to cefoxitin and cefotetan were 15.4% and 20.5%. The primary infectious diseases were postoperative infection after intestinal surgery（22.2%）,empyema （17.5%） and appendix perforation（11.1%）. Conclusions Gram-negative no-spore forming anaerobic bacteria and Gram-positive Clostridium are main anaerobic bacteria for bloodstream infection. When the results of drug susceptibility test were not available,the clinicians could choose metronidazole,carbapenem and enzyme inhibitors as first choice. The primary infectious diseases mainly occur in intestine,chest and female reproductive tract. It should be prevented as soon as possible,which is conducive to reducing the occurrence and development of bloodstream infection.

Key words: Anaerobic bacterium, Drug resistance, Primary infectious disease, Bloodstream infection