关键词: C反应蛋白/白蛋白比值, 格拉斯哥预后评分, 生存期, 肺癌

Abstract:

Objective To evaluate C-reactive protein（CRP）/albumin（Alb） ratio in the prognosis of lung cancer. Methods The clinical and laboratory data of 121 patients with lung cancer were recorded retrospectively. Neutrophil/lymphocyte ratio （NLR）,platelet/lymphocyte ratio （PLR）,systemic immune-inflammation index （SII）,Glasgow prognostic score （GPS） and CRP/Alb ratio were determined before chemotherapy or surgery,and the results were analyzed statistically. Results There was no statistical significance for survival time between different pathological types and between carcinoembryonic antigen（CEA） normal and abnormal groups （P>0.05）. The survival time of males was shorter than that of females（P<0.05）,and the survival time of CRP or Alb abnormal group was shorter than that of CRP or Alb normal group （P<0.05）. There was no statistical significance for survival time among NLR,PLR and SII normal and abnormal groups （P>0.05）,while the survival time of GPS 0 group was longer than those of GPS 1 and GPS 2 groups （P<0.05）. The survival time of CRP/Alb ratio normal group was longer than that of CRP/Alb ratio abnormal group （P<0.01）. CRP/Alb ratio in different pathological types and clinical stages had no statistical significance （P>0.05）. Conclusions CRP/Alb ratio may be a prognostic indicator for lung cancer,independently to pathological types and clinical stages. High CRP/Alb ratio suggests a poor prognosis.

Key words: C-reactive protein/albumin ratio, Glasgow prognostic score, Survival time, Lung cancer