检验医学 ›› 2016, Vol. 31 ›› Issue (3): 155-158.DOI: 10.3969/j.issn.1673-8640.2016.03.001

• 儿童感染性疾病专题 •    下一篇

运用多种方法提升儿童感染性疾病的实验诊断能力

徐锦   

  1. 复旦大学附属儿科医院临床检验中心,上海 201102
  • 收稿日期:2016-01-27 出版日期:2016-03-30 发布日期:2016-04-08
  • 作者简介:null

    作者简介:徐 锦,女,1970年生,博士,研究员,主要从事临床病毒学、分子流行病学及感染与免疫研究。

Improving laboratory diagnosis ability of infectious diseases in children using multiple assays

XU Jin.   

  1. Clinical Laboratory Center,Children’s Hospital of Fudan University,Shanghai 201102,China
  • Received:2016-01-27 Online:2016-03-30 Published:2016-04-08

摘要:

感染性疾病仍然是全世界儿童健康的主要危害。病原体的早期确定和准确鉴别对感染性疾病的预防及有效控制有非常重要的意义,尤其对于控制目前抗菌药物的过量使用以及在细菌性感染中不必要的抗病毒药物的使用有着实用意义。因此,需要结合各种技术手段和方法,建立和完善用于临床实验室和床边的各种快速鉴定病原体或检测宿主生物标志物的诊断系统,并深入认识病原体基因型的流行特点及与其致病性的可能关系,提升儿童感染性疾病的诊断能力。

关键词: 儿童, 感染性疾病, 诊断, 等温扩增, 生物标志物

Abstract:

Infectious disease is a major problem for children' s health worldwide. Early and accurate identification and diagnosis of pathogens play a very important role for the prevention and control of infectious diseases,especially for the control of antibiotics and anti-viral medicine abuse. In order to improve the laboratory ability for the diagnosis of infectious diseases in children,a variety of clinical and on-site diagnostic systems should be developed for the rapid determination of pathogens or host biomarkers by utilizing multiple techniques and assays,and the molecular epidemiological characteristics of pathogen genotype and its possible relationship with pathogenesis should be deeply investigated.

Key words: Child, Infectious diseases, Diagnosis, Isothermal amplification, Biomarkers

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