冠心病患者血清内脂素和脂联素水平的变化及临床意义

检验医学 ›› 2012, Vol. 27 ›› Issue (5): 349-351.

冠心病患者血清内脂素和脂联素水平的变化及临床意义

焦路阳

1．新乡医学院第一附属医院检验科，河南卫辉 453100； 2.新乡医学院研究生处，河南新乡 453003

收稿日期:2012-04-05 修回日期:2012-04-15 出版日期:2012-05-30 发布日期:2012-05-10
通讯作者: 袁　宇，联系电话：0373-4402702。
作者简介:焦路阳，男，1971年生，副主任技师，主要从事临床化学检验工作。

The changes and clinical significance of serum visfatin and adiponectin levels in patients with coronary heart disease

1.Department of Clinical Laboratory，the First Affiliated Hospital of Xinxiang Medical University, Henan Weihui 453100，China；2. Graduate Department，Xinxiang Medical University，Henan Xinxiang 453003，China

Received:2012-04-05 Revised:2012-04-15 Online:2012-05-30 Published:2012-05-10

摘要/Abstract

摘要： 目的　结合C反应蛋白（CRP），探讨血清内脂素、脂联素与冠心病的关系及可能的作用机制。方法　将经冠状动脉造影确诊的270例冠心病患者根据临床表现分为3组：稳定性心绞痛（SAP）组125例、不稳定性心绞痛（UAP）组109例、急性心肌梗死（AMI）组36例。另选取健康体检者20名作为对照组。采用酶联免疫吸附试验（ELISA）测定血清内脂素、脂联素水平。同时检测CRP、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）、丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、尿素氮（BUN）及肌酐（Cr）水平。采用多元相关分析方法分析内脂素、脂联素与其他指标之间的相关性。结果　冠心病组血清CRP、内脂素水平均明显高于对照组（P均﹤0.01）；脂联素水平则低于对照组（P<0.01）。AMI组、UAP组及SAP组间血清CRP、内脂素和脂联素差异均有统计学意义（P均﹤0.05）。多元相关分析显示，血清内脂素与CRP、TG、LDL-C呈正相关（r分别为0.929、0.756、0.793，P均<0.001），与脂联素及HDL-C呈负相关（r分别为－0.351、－0.699，P均<0.001）；脂联素与CRP、TG及LDL-C呈负相关（r分别为－0.873、－0.639、－0.799，P均﹤0.001）；与HDL-C呈正相关（r=0.681，P<0.001）。结论　血清内脂素、脂联素均可能是冠心病的危险因素，推测二者可能与CRP相互作用、共同参与了冠心病的发生发展。

关键词: C反应蛋白, 脂联素, 内脂素, 冠心病

Abstract: Objective　To investigate the relationship of serum visfatin， adiponectin and coronary heart disease with C reactive protein (CRP) and its possible mechanism. Methods　A total of 270 patients with coronary heart disease confirmed by coronary angiography were enrolled. According to clinical manifestations, they were classified into 3 groups：stable angina pectoris （SAP） group (125 cases), unstable angina pectoris （UAP） group (109 cases) and acute myocardial infarction （AMI） group (36 cases). Another 20 healthy subjects were as control group. The serum visfatin and adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). The levels of CRP, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting glucose (FPG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (BUN) and creatinine (Cr) were also determined. The multiple correlation analysis method was used to analyze the correlation of visfatin and adiponectin with other indices. Results　In the coronary heart disease group, CRP and serum visfatin levels were significantly higher than those in control group（P<0.01）. The serum adiponectin level was lower than that of control group （P<0.01）. In AMI group， UAP group and SAP group, CRP， serum visfatin and adiponectin were statisically significant （P< 0.05）. The multiple correlation analysis showed that serum visfatin was positively correlated with CRP， TG and LDL-C （r=0.929，0.756 and 0.793, P<0.001）. The serum visfatin was negatively correlated with adiponectin and HDL-C （r=-0.351 and -0.699,P<0.001）. The serum adiponectin was negatively correlated with CRP, TG and LPL-C (r=-0.873，-0.639 and -0.799, P<0.001), and was positively correlated with HDL-C (r=0.681,P<0.001). Conclusions　Serum visfatin and adiponectin may be risk factors for coronary heart disease， and they may interact with CRP，and be involved in the occurrence and development of coronary heart disease.

Key words: C reactive protein, Adiponectin, Visfatin, Coronary heart disease

焦路阳;王　宇;袁　宇. 冠心病患者血清内脂素和脂联素水平的变化及临床意义[J]. 检验医学, 2012, 27(5): 349-351.

JIAO Lu-Yang;WANG Yu;YUAN Yu. The changes and clinical significance of serum visfatin and adiponectin levels in patients with coronary heart disease[J]. , 2012, 27(5): 349-351.

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