血清淀粉样蛋白A在疾病中的作用机制及应用研究进展

doi:10.3969/j.issn.1673-8640.2021.07.017

摘要/Abstract

摘要：

血清淀粉样蛋白A（SAA）属于急性时相反应蛋白,在感染急性期、炎症反应、组织损伤时迅速升高,在恢复期迅速下降。SAA与细菌或病毒感染、动脉粥样硬化、肿瘤、移植排斥反应、类风湿性关节炎、淀粉样病变等密切相关。文章主要就淀粉样蛋白（AA）超家族的结构、功能、检测方法及SAA在各种疾病中的作用机制及应用进展作一综述。

关键词: 血清淀粉样蛋白A, 感染, 冠心病, 肿瘤, 炎症

Abstract:

Serum amyloid A（SAA） is an acute phase-reactive protein that rapidly increases in the acute phase of infection,inflammation and tissue damage,and rapidly declines during the recovery phase of the diseases. There are important links between SAA and infection caused by bacteria or viruses,atherosclerosis,tumors,transplant rejection,rheumatoid,amyloidosis and so on. This review focuses on the structure,function and determination method of the SAA superfamily and the development of mechanisms and applications of SAA and clinical diseases.

Key words: Serum amyloid A, Infection, Coronary heart disease, Tumor, Inflammation

中图分类号:

R446.1

刘锦燕, 赵珺涛, 项明洁. 血清淀粉样蛋白A在疾病中的作用机制及应用研究进展[J]. 检验医学, 2021, 36(7): 756-760.

LIU Jinyan, ZHAO Juntao, XIANG Mingjie. Mechanism and application of serum amyloid A in clinical diseases[J]. Laboratory Medicine, 2021, 36(7): 756-760.

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