检验医学 ›› 2012, Vol. 27 ›› Issue (7): 592-594.

• 免疫学检验论著 • 上一篇    下一篇

血清CA125测定对卵巢高、低级别浆液性癌鉴别诊断价值的回顾性研究

毛佩敏,刘晓艳   

  1. 复旦大学附属妇产科医院检验科,上海 200011
  • 收稿日期:2012-06-13 修回日期:2012-06-26 出版日期:2012-07-30 发布日期:2012-07-05
  • 通讯作者: 刘晓艳,联系电话:021-63455050-6223。
  • 作者简介:毛佩敏,女,1971年生,主管技师,目前主要从事免疫学检验工作。

A retrospective descriptive study on the significance of carbohydrate antigen 125 in differential diagnosis of high and low grade serous ovarian cancer

  1. Department of Clinical Laboratory,Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200011,China
  • Received:2012-06-13 Revised:2012-06-26 Online:2012-07-30 Published:2012-07-05

摘要: 目的 探讨血清糖类抗原125(CA125)测定对卵巢浆液性上皮良恶性肿瘤间及高、低级别浆液性癌间鉴别诊断的价值。方法 回顾性研究128例卵巢肿瘤患者的病例资料。比较高级别、低级别浆液性上皮性卵巢癌患者与浆液性囊腺瘤患者各组间术前血CA125值。结果 高级别、低级别浆液性上皮性卵巢癌患者术前血CA125值均高于浆液性囊腺瘤患者(P=0.002、P=0.003)。高级别与低级别浆液性上皮性卵巢癌患者之间术前血CA125值相比差异无统计学意义(P=0.426)。结论 血清CA125测定对卵巢良恶性肿瘤的鉴别具有意义,但对高级别和低级别浆液性上皮性卵巢癌的区分没有作用,需寻找更好的血清学指标来鉴别二者。

关键词: 糖类抗原125, 卵巢肿瘤, 高级别, 低级别

Abstract: Objective To investigate the differential diagnosis significance of high and low grade serous ovarian cancer with carbohydrate antigen 125(CA125). Methods A total of 128 patients with ovarian tumors were retrospectively analyzed. The serum levels of CA125 of patients with high and low grade serous ovarian cancer and cystadenocarcinoma were determined preoperatively. Results Serum levels of CA125 among the high and low grade serous ovarian cancer patients were significantly higher than those of serous cystadenocarcinoma patients,respectively(P=0.002,P=0.003). The serum levels of CA125 between the high and low grade serous ovarian cancer patients showed no statistical significance(P=0.426). Conclusions Serum CA125 plays an important role in the differential diagnosis of malignant ovarian tumors,but it cannot identify the high and low grade serous ovarian cancer.

Key words: Carbohydrate Antigen 125, ovarian cancer, high grade, low grade