尿中性粒细胞明胶酶相关性脂质运载蛋白检测对SLE肾病的临床意义

检验医学 ›› 2012, Vol. 27 ›› Issue (3): 189-191.

尿中性粒细胞明胶酶相关性脂质运载蛋白检测对SLE肾病的临床意义

邬叶红¹,俆燕萍²,赵荣平²

1.复旦大学生命科学院，上海 200433；2.上海交通大学医学院附属仁济医院检验科，上海 200126

收稿日期:2012-01-12 出版日期:2012-03-30 发布日期:2012-03-16
通讯作者: 赵荣平，联系电话：021-68383289。
作者简介:邬叶红，女，1978年生，学士，主管技师，主要从事临床免疫工作。

The clinical significance of detecting urinary neutrophil gelatinase-associated lipocalin in SLE kidney disease

1.The Life Science Academy, Fudan University，Shanghai 200433, China; 2. Department of Clinical Laboratory, Renji Hospital, Shanghai Jiaotong University School of Medicine，Shanghai 200126, China

Received:2012-01-12 Online:2012-03-30 Published:2012-03-16

摘要/Abstract

摘要： 目的　探讨尿中性粒细胞明胶酶相关性脂质运载蛋白(NGAL)在系统性红斑狼疮(SLE)患者肾脏损伤中的临床意义。方法　收集124例SLE患者和30名健康体检者尿液，采用速率散射比浊法检测尿微量白蛋白(Alb)，并依据尿中Alb将SLE患者分为A、B、C 3组。30名健康体检者为对照组，用酶免疫法定量测定各组NGAL。结果　SLE 患者 A、B、C 3组和对照组尿NGAL分别为3.51±0.49、5.48±0.98、7.89±1.71、3.37±0.31 μg/L；A组(Alb<30mg/L)和对照组间差异无统计学意义（P>0.05）；B组(Alb 30～100 mg/L)和对照组间差异有统计学意义（P<0.01）；C组(Alb 100～500 mg/L)和对照组间差异有统计学意义（P<0.01）；A、B、C 3组间差异有统计学意义（P<0.05）。SLE患者尿NGAL与Alb之间呈正相关性（r=0.84）。结论　当Alb增高时尿NGAL随之增高，尿NGAL可用于判断SLE患者肾小管间质功能损伤情况。

Abstract: Objective　To investigate the clinical significance of urinary neutrophil gelatinase-associated lipocalin (NGAL) in kidney damage of systemic lupus erythematosus (SLE) patients. Methods　The urine of 124 SLE patients and 30 healthy subjects were collected. The urinary microalbumin (Alb) was detected by rate nephelometry. According to the results of Alb, the SLE patients were classified into 3 groups (Group A, B and C). The 30 healthy subjects were as the control group. The NGAL was detected by enzyme immunoassay quantitatively. Results　The urinary NGAL in Group A, B and C of SLE patients and control group were 3.51±0.49, 5.48±0.98, 7.89±1.71 and 3.37±0.31 μg/L. There was no statistical significance of urinary NGAL between Group A(Alb<30mg/L) and control group（P>0.05）. There was statistical significance of urinary NGAL between Group B (Alb: 30-100 mg/L) and control group（P<0.01）. There was statistical significance of urinary NGAL between Group C (Alb: 100-500 mg/L) and control group（P<0.01）. There was statistical significance of urinary NGAL among Group A, B and C（P<0.05）.The positive correlation about the Albu and urinary NGAL was 0.84 in SLE patients. Conclusions　Urinary NGAL increases when Alb rises，and urinary NGAL can be used to judge SLE patients with tubular interstitial function damage.

Key words: Urinary neutrophil gelatinase-associated lipocalin, Systemic lupus erythematosus, Urinary microalbumin

邬叶红;赵荣平;徐燕萍. 尿中性粒细胞明胶酶相关性脂质运载蛋白检测对SLE肾病的临床意义[J]. 检验医学, 2012, 27(3): 189-191.

WU Yehong;ZHAO Rongping;XU Yanping. The clinical significance of detecting urinary neutrophil gelatinase-associated lipocalin in SLE kidney disease[J]. , 2012, 27(3): 189-191.

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