检验医学 ›› 2012, Vol. 27 ›› Issue (1): 57-59.

• 生物化学检验论著 • 上一篇    下一篇

血清胃蛋白酶原检测在胃部疾病诊断中的意义

  

  1. 上海市复旦大学附属中山医院青浦分院,上海 201700
  • 收稿日期:2011-08-10 出版日期:2012-01-20 发布日期:2012-01-20
  • 作者简介:费凤英,女,1974年生,本科,副主任技师,主要从事生物化学检验工作。

Clinical significance of serum pepsinogen determination in the diagnosis of various gastric diseases

  1. Shanghai Qingpu Branch,Zhongshan Hospital, Fudan University, Shanghai 201700, China
  • Received:2011-08-10 Online:2012-01-20 Published:2012-01-20
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关键词: 胃蛋白酶原, 胃癌, 化学发光免疫分析

Abstract: Objective To study the relationship between serum pepsinogen (PG) Ⅰ/PGⅡ ratio with various gastric diseases, and provide the reference for screening in the early diagnosis of gastric cancer.   Methods Chemiluminesent microparticle immunoassay was used to determine the levels of PGⅠ and PGⅡ and the ratio of PGⅠ/PGⅡ in 145 patients with various gastric diseases. The results were analyzed statistically.  Results Compared with patients with chronic nonatrophic gastritis,the serum PGⅠ/PGⅡ ratios in patients with gastric ulcer and atrophic gastritis were lower (P<0.05), and that in patients with gastric cancer was significantly lower (P<0.001). There was no statistical significance of PGⅠ/PGⅡ ratio among atrophic gastritis, gastric cancer and gastric ulcer (P> 0.05).  Conclusions The changes of serum PGⅠ/PGⅡ ratio are related with gastric pathological changes, and the PGⅠ/PGⅡ ratio has a clinical significance for the early screening of gastric cancer and gastric precancerosis.

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