非妊娠成人无乳链球菌感染临床特点及分子流行病学研究进展

doi:10.3969/j.issn.1673-8640.2022.08.017

摘要/Abstract

摘要：

无乳链球菌（Streptococcus agalactiae）是引起新生儿和孕产妇侵袭性感染的主要病原菌之一。近年来,非妊娠成人无乳链球菌感染率显著上升。目前,非妊娠成人无乳链球菌感染的临床特点和分离自这一人群的无乳链球菌分子流行病学特点尚不明确,文章对其进行综述,以期为此类疾病的诊治及预防控制提供参考。

关键词: 无乳链球菌, 非妊娠成人, 临床特点, 分子流行病学, 荚膜血清型, 多位点序列分型

Abstract:

Streptococcus agalactiae has known as the leading cause of invasive disease in neonates and pregnant women. However,the morbidity of Streptococcus agalactiae infection in non-pregnant adults is increasing rapidly. The clinical characteristics of Streptococcus agalactiae infection and the molecular epidemiology of Streptococcus agalactiae isolated from non-pregnant adults have rare understood. The review provides a reference for the diagnosis,treatment prevention and control of this disease.

Key words: Streptococcus agalactiae, Non-pregnant adult, Clinical characteristic, Molecular epidemiology, Capsular polysaccharide serotype, Multiple locus sequence typing

中图分类号:

R446.1

刘婧娴, 陈星月, 赵晶, 刘瑛. 非妊娠成人无乳链球菌感染临床特点及分子流行病学研究进展[J]. 检验医学, 2022, 37(8): 793-797.

LIU Jingxian, CHEN Xingyue, ZHAO Jing, LIU Ying. Clinical characteristics and molecular epidemiology of Streptococcus agalactiae infection in non-pregnant adults[J]. Laboratory Medicine, 2022, 37(8): 793-797.

参考文献 40

[1]	RUSSELL N J, SEALE A C, O'DRISCOLL M, et al. Maternal colonization with group B Streptococcus and serotype distribution worldwide:systematic review and meta-analyses[J]. Clin Infect Dis, 2017, 65(Suppl 2):S100-S111. DOI URL
[2]	FRANCOIS WATKINS L K, MCGEE L, SCHRAG S J, et al. Epidemiology of invasive group B streptococcal infections among nonpregnant adults in the United States,2008-2016[J]. JAMA Intern Med, 2019, 179(4):479-488. DOI URL
[3]	GRAUX E, HITES M, MARTINY D, et al. Invasive group B Streptococcus among non-pregnant adults in Brussels-Capital Region,2005-2019[J]. Eur J Clin Microbiol Infect Dis, 2021, 40(3):515-523. DOI URL
[4]	ABDELRADI A, MURPHY A, AHASIC A M. Invasive Streptococcus agalactiae causing meningitis,ventriculitis,and endocarditis in a non-pregnant adult[J]. Cureus, 2020, 12(11):e11412.
[5]	CRUM-CIANFLONE N F. An unusual case of a large,sporadic intra-abdominal abscess due to group B Streptococcus and a review of the literature[J]. Infection, 2015, 43(2):223-227. DOI URL
[6]	SUNKARA B, BHEEMREDDY S, LORBER B, et al. Group B Streptococcus infections in non-pregnant adults:the role of immunosuppression[J]. Int J Infect Dis, 2012, 16(3):e182-e186.
[7]	LEE N Y, YAN J J, WU J J, et al. Group B streptococcal soft tissue infections in non-pregnant adults[J]. Clin Microbiol Infect, 2005, 11(7):577-579. DOI URL
[8]	VUILLEMIN X, HAYS C, PLAINVERT C, et al. Invasive group B Streptococcus infections in non-pregnant adults:a retrospective study,France,2007-2019[J]. Clin Microbiol Infect, 2021, 27(1):129.e1-129.e4.
[9]	HO C M, CHI C Y, HO M W, et al. Clinical characteristics of group B streptococcus bacteremia in non-pregnant adults[J]. J Microbiol Immunol Infect, 2006, 39(5):396-401.
[10]	ALIZZI M, RATHNAYAKE R, SIVABALAN P, et al. Group B streptococcal bacteraemia-changing trends in a tropical region of Australia[J]. Intern Med J, 2022, 52(5):800-807. DOI URL
[11]	CHO S Y, KANG C I, KIM J, et al. Association of liver cirrhosis with group B streptococcal bacteremia in non-pregnant adults[J]. J Infect, 2013, 67(6):617-619. DOI URL
[12]	BENMIMOUN B, PAPASTEFANAKI F, PÉRICHON B, et al. An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossing[J]. Nat Commun, 2020, 11(1):6106. DOI URL
[13]	PAYUS A O, CLARENCE C, AZMAN ALI R. Group B streptococcal meningitis in a healthy young woman:a case report[J]. Int J Gen Med, 2020, 13:861-864. DOI URL
[14]	HIRAI J, KINJO T, HARANAGA S, et al. A case report of cerebral meningitis caused by penicillin-non-susceptible group B Streptococcus in an immunocompromised adult patient[J]. Infect Drug Resist, 2020, 13:2155-2160. DOI URL
[15]	YOSHIDA M, YOKOKURA S, NISHIDA T, et al. Endogenous endophthalmitis caused by group B streptococcus;case reports and review of 35 reported cases[J]. BMC Ophthalmol, 2020, 20(1):126. DOI URL
[16]	TCHANA-SATO V, HANS G, FRIPPIAT F, et al. Streptococcus agalactiae infective endocarditis:analysis of eight surgical cases from a single centre[J]. Infect Dis(Lond), 2021, 53(3):189-195.
[17]	LOUBET P, KOUMAR Y, LECHICHE C, et al. Clinical features and outcome of Streptococcus agalactiae bone and joint infections over a 6-year period in a French university hospital[J]. PLoS One, 2021, 16(3):e0248231.
[18]	SENDI P, CHRISTENSSON B, UÇKAY I, et al. Group B streptococcus in prosthetic hip and knee joint-associated infections[J]. J Hosp Infect, 2011, 79(1):64-69. DOI URL
[19]	COLLIN S M, SHETTY N, GUY R, et al. Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide:a systematic review and meta-analysis[J]. Int J Infect Dis, 2019, 83:116-129. DOI URL
[20]	JOHN P P, BAKER B C, PAUDEL S, et al. Exposure to moderate glycosuria induces virulence of group B Streptococcus[J]. J Infect Dis, 2021, 223(5):843-847. DOI URL
[21]	SHING S R, RAMOS A R, PATRAS K A, et al. The fungal pathogen Candida albicans promotes bladder colonization of group B Streptococcus[J]. Front Cell Infect Microbiol, 2020, 9:437. DOI URL
[22]	SLOTYED H C, KONG F, LAMBERTSEN L, et al. Serotype Ⅸ,a proposed new Streptococcus agalactiae serotype[J]. J ClinMicrobiol, 2007, 45(9):2929-2936.
[23]	FURFARO L L, CHANG B J, PAYNE M S. Perinatal Streptococcus agalactiae epidemiology and surveillance targets[J]. ClinMicrobiol Rev, 2018, 31(4):e00049-18.
[24]	BARSHAK M B. Group B Streptococcus,an a-list pathogen in nonpregnant adults[J]. JAMA Intern Med, 2019, 179(4):488-489. DOI URL
[25]	BJÖRNSDÓTTIR E S, MARTINS E R, ERLENDSDÓTTIR H, et al. Changing epidemiology of group B streptococcal infections among adults in Iceland:1975-2014[J]. Clin Microbiol Infect, 2016, 22(4):379.e9-379.e16. DOI URL
[26]	VIGLIAROLO L, ARIAS B, SUÁREZ M, et al. Argentinian multicenter study on urinary tract infections due to Streptococcus agalactiae in adult patients[J]. J Infect Dev Ctries, 2019, 13(1):77-82. DOI URL
[27]	TSAI M H, HSU J F, LAI M Y, et al. Molecular characteristics and antimicrobial resistance of group B streptococcus strains causing invasive disease in neonates and adults[J]. Front Microbiol, 2019, 10:264. DOI URL
[28]	KARDOS S, TÓTHPÁL A, LAUB K, et al. High prevalence of group B streptococcus ST17 hypervirulent clone among non-pregnant patients from a Hungarian venereology clinic[J]. BMC Infect Dis, 2019, 19(1):1009. DOI URL
[29]	DE FIGUEIREDO SANCHES G, LANNES-COSTA P S, CRISTOFORÊTO M C, et al. Streptococcus agalactiae strains isolated from cancer patients in Rio de Janeiro,Brazil[J]. Braz J Microbiol, 2021, 52(1):303-310. DOI URL
[30]	FAVERO L M, CHIDEROLI R T, FERRARI N A, et al. In silico prediction of new drug candidates against the multidrug-resistant and potentially zoonotic fish pathogen serotype Ⅲ Streptococcus agalactiae[J]. Front Genet, 2020, 11:1024. DOI URL
[31]	BARKHAM T, ZADOKS R N, AZMAI M N A, et al. One hypervirulent clone,sequence type 283,accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia[J]. PLoS Negl Trop Dis, 2019, 13(6):e0007421.
[32]	OMURA Y, KUSAMA Y, TAKEUCHI N, et al. Mediastinal,subcutaneous and multiple muscular abscesses caused by group B streptococcus serotype Ⅷ in a type 2 diabetes mellitus patient[J]. J Infect Chemother, 2018, 24(5):401-403. DOI URL
[33]	HIRAI N, KASAHARA K, UNO K, et al. Infective endocarditis complicated by intraventricular abscesses,pericarditis,and mycotic aneurysm due to an emerging strain of serotype Ⅵ Streptococcus agalactiae[J]. Jpn J Infect Dis, 2017, 70(6):685-686. DOI URL
[34]	TAZI A, MORAND P C, RÉGLIER-POUPET H, et al. Invasive group B streptococcal infections in adults,France(2007-2010)[J]. Clin Microbiol Infect,2011, 17(10):1587-1589. DOI URL
[35]	NIE S, LU X, JIN Z, et al. Characterization of group B Streptococcus isolated from sterile and non-sterile specimens in China[J]. Diagn Microbiol Infect Dis, 2018, 92(1):56-61. DOI URL
[36]	MAEDA T, TAKAYAMA Y, FUJITA T, et al. Comparison between invasive and non-invasive Streptococcus agalactiae isolates from human adults,based on virulence gene profiles,capsular genotypes,sequence types,and antimicrobial resistance patterns[J]. Jpn J Infect Dis, 2021, 74(4):316-324. DOI URL
[37]	PHOOMPOUNG P, PIROGARD N, LEELAPORN A, et al. Incidence of invasive Group B Streptococcus(iGBS)infections and the factors associated with iGBS mortality in adults during 2013-2017:a retrospective study at Thailand's largest national tertiary referral center[J]. Ann Med, 2021, 53(1):715-721. DOI URL
[38]	GUO Y, DENG X, LIANG Y, et al. The draft genomes and investigation of serotype distribution,antimicrobial resistance of group B Streptococcus strains isolated from urine in Suzhou,China[J]. Ann Clin Microbiol Antimicrob, 2018, 17(1):28. DOI URL
[39]	NISHIYAMA N, KINJO T, UECHI K, et al. Clinical and bacterial features of Group B streptococci with reduced penicillin susceptibility from respiratory specimens:a case-control study[J]. Eur J Clin Microbiol Infect Dis, 2021, 41(1):1-8. DOI URL
[40]	MUDZANA R, MAVENYENGWA R T, GUDZA-MUGABE M. Analysis of virulence factors and antibiotic resistance genes in group B streptococcus from clinical samples[J]. BMC Infect Dis, 2021, 21(1):125. DOI URL