关键词: 钙卫蛋白, 粪便, 炎症性肠病, 儿童

Abstract: Objective To investigate the role of fecal calprotectin in children's inflammatory bowel disease（IBD）. Methods Totally,125 children with IBD（IBD group） were enrolled,there were 33 cases in the attack stage of Crohn's disease,31 cases in acute enteritis,41 cases in ulcerative colitis,20 cases in abdominal allergic purpura and 19 cases in the remission stage of Crohn's disease,and there were 33 healthy children who underwent physical examination as healthy control group. Fecal calprotectin levels of all the subjects were determined. Receiver operating characteristic（ROC） curve was used to evaluate the efficiency of fecal calprotectin in identifying the onset and remission stages of Crohn's disease. Results The fecal calprotectin levels in IBD group was higher than that in healthy control group（P<0.000 1）. The fecal calprotectin levels of children with different types of IBD were higher than those of healthy control group（P<0.000 1）,but there was no statistical significance in the fecal calprotectin levels of children with different types of IBD（P>0.05）. The fecal calprotectin level in Crohn's disease attack group was higher than that in remission group（P<0.000 1）. ROC curve analysis showed that the area under curve（AUC） of fecal calprotectin in identifying the onset and remission stages of Crohn's disease was 0.933 8,the optimal cut-off value was 59.91 μg/g,the sensitivity was 89.47%,and the specificity was 82.86%. Conclusions Fecal calprotectin can be used as an auxiliary diagnostic indicator of IBD and an identification indicator between attack and remission stages of Crohn's disease.

Key words: Calprotectin, Feces, Inflammatory bowel disease, Children