幽门螺杆菌传播和定植机制研究进展

doi:10.3969/j.issn.1673-8640.2020.03.020

摘要/Abstract

摘要：

幽门螺杆菌是一种定植于宿主胃黏膜上皮细胞层的微需氧、螺旋状革兰阴性杆菌。幽门螺杆菌感染会持续数十年,可致胃肠道疾病,甚至引发胃癌。世界卫生组织将幽门螺杆菌定义为Ⅰ类致癌因子,其感染率非常高,我国部分地区感染率甚至超过80%,且呈逐年上升的趋势。幽门螺杆菌感染影响因素较多,但传播和定植是关键。文章就幽门螺杆菌在传播和定植方面的研究进展作一综述。

关键词: 幽门螺杆菌, 传播, 定植

Abstract:

Helicobacter pylori is a microaerobic,helical Gram-negative bacterium colonized in the host gastric epithelial cell layer. Its infection can last for decades,and it can cause a series of gastrointestinal disorders,even gastric cancer. Helicobacter pylori has been defined as a classⅠcarcinogen factor by World Health Organization. Helicobacter pylori has a high infection rate. The infection rate of Helicobacter pylori in China can reach over 80%,and the infection rate is increasing year by year. Helicobacter pylori infection depends on many factors,and transmission and colonization are the key influencing factors. This review mainly focuses on the transmission and colonization of Helicobacter pylori.

Key words: Helicobacter pylori, Transmission, Colonization

中图分类号:

R446.1

王佳静, 邵洲杰, 叶鸿雁. 幽门螺杆菌传播和定植机制研究进展[J]. 检验医学, 2020, 35(3): 282-286.

WANG Jiajing, SHAO Zhoujie, YE Hongyan. Research progress of the mechanism of Helicobacter pylori transmission and colonization[J]. Laboratory Medicine, 2020, 35(3): 282-286.

参考文献 49

[1]	MOSS S F.The clinical evidence linking,Helicobacter pylori,to gastric cancer[J]. Cell Mol Gastroenterol Hepatol,2016,3(2):183-191.
[2]	UKASZ H,JACEK I.Diet and Helicobacter pylori infection[J]. Gastroenterology Review,2016,3:150-154.
[3]	YAMANAKA K,MIYATANI H,YOSHIDA Y,et al.Malignant transformation of a gastric hyperplastic polyp in a context of Helicobacter pylori-negative autoimmune gastritis:a case report[J]. BMC Gastroenterology,2016,16(1):130.
[4]	ZHANG R G,DUAN G C,FAN Q T,et al.Role of Helicobacter pylori infection in pathogenesis of gastric carcinoma[J]. World J Gastrointest Pathophysiology,2016,7(1):97-107.
[5]	KUO C H,CHEN Y H,GOH K L,et al.Helicobacter pylori and systemic disease[J]. Gastroenterol Res Pract,2014,2014:358494.
[6]	ZAMANI M,MASROUR-ROUDSARI J,ZAMANI V.Hematologic disorder:a manifestation of Helicobacter pylori infection[J]. Caspian J Intern Med,2017,8(2):133-134.
[7]	SOTUNEH N,HOSSEINI S R,SHOKRI-SHIRVANI J,et al.Helicobacter pylori infection and metabolic parameters:is there an association in elderly population?[J]. Int J Prev Med,2014,5(12):1537-1542.
[8]	VAFAEIMANESH J,BAGHERZADEH M,HEIDARI A,et al.Diabetic patients infected with Helicobacter pylori have a higher insulin resistance degree[J]. Caspian J Intern Med,2014,5(3):137-142.
[9]	ZHANG X,SHI D,LIU Y P,et al.Effects of the Helicobacter pylori virulence factor CagA and ammonium ion on mucins in AGS cells[J]. Yonsei Med J,2018,59(5):633-642.
[10]	NEJATI S,KARKHAH A,DARVISH H,et al.Influence of Helicobacter pylori virulence factors CagA and VacA on pathogenesis of gastrointestinal disorders[J]. Microb Pathog,2018,117:43-48.
[11]	KABLE M E,HANSEN L M,STYER C M,et al.Host determinants of expression of the Helicobacter pylori BabA adhesin[J]. Sci Rep,2017,7:46499.
[12]	BENKTANDER J,BARONE A,JOHANSSON M M,et al.Helicobacter pylori SabA binding gangliosides of human stomach[J]. Virulence,2018,9(1):738-751.
[13]	CHIURILLO M A,MORAN Y,CAÑAS M,et al. Genotyping of Helicobacter pylori virulence-associated genes shows high diversity of strains infecting patients in western Venezuela[J]. Int J Infect Dis,2013,17(9):e750-e756.
[14]	BEN MANSOUR K,FENDRI C,BATTIKH H,et al.Multiple and mixed Helicobacter pylori infections:comparison of two epidemiological situations in Tunisia and France[J]. Infect Genet Evol,2016,37:43-48.
[15]	LEJA M,AXON A,BRENNER H.Epidemiology of Helicobacter pylori infection[J]. Helicobacter,2016,21(Suppl 1):3-7.
[16]	INOUE M.Changing epidemiology of Helicobacter pylori in Japan[J]. Gastric Cancer,2017,20(Suppl 1):3-7.
[17]	BASTOS J,PELETEIRO B,BARROS R,et al.Sociodemographic determinants of prevalence and incidence of Helicobacter pyloriinfection in Portuguese adults[J]. Helicobacter,2013,18(6):413-422.
[18]	BURUCOA C,AXON A.Epidemiology of Helicobacter pylori infection[J]. Helicobacter,2017,22(Suppl 1):10.
[19]	ZHANG M,ZHOU Y Z,LI X Y,et al.Seroepidemiology of Helicobacter pylori infection in elderly people in the Beijing region,China[J]. World J Gastroenterol,2014,20(13):3635-3639.
[20]	ZHANG Y,LI J X.Investigation of current infection with Helicobacter pylori in children with gastrointestinal symptoms[J]. Zhongguo Dang Dai Er Ke Za Zhi,2012,14(9):675-677.
[21]	OKUDA M,MIYASHIRO E,BOOKA M,et al.Helicobacter pylori colonization in the first 3 years of life in Japanese children[J]. Helicobacter,2007,12(4):324-327.
[22]	TESTERMAN T L,MORRIS J.Beyond the stomach:an updated view of Helicobacter pylori pathogenesis,diagnosis,and treatment[J]. World J Gastroenterol,2014,20(36):12781-12808.
[23]	TESTERMAN T L, MORRIS J.Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment[J]. World J Gastroenterol, 2014, 20(36):12781-12808.
[24]	NIV Y.H pylori recurrence after successful eradication[J]. World J Gastroenterol,2008,14(10):1477-1478.
[25]	OSAKI T,KONNO M,YONEZAWA H,et al.Analysis of intra-familial transmission of Helicobacter pylori in Japanese families[J]. J Med Microbiol,2015,64(Pt 1):67-73.
[26]	LINZ B,WINDSOR H M,GAJEWSKI J,et al.Helicobacter pylori genomic microevolution during naturally occurring transmission between adults[J]. PLoS One,2013,8(12):e82187.
[27]	TOMLINSON M S,BOMMARITO P A,MARTIN E M,et al.Microorganisms in the human placenta are associated with altered CpG methylation of immune and inflammation-related genes[J]. PLoS One,2017,12(12):e0188664.
[28]	URITA Y,WATANABE T,KAWAGOE N,et al.Role of infected grandmothers in transmission of Helicobacter pylori to children in a Japanese rural town[J]. J Paediatr Child,2013,49(5):394-398.
[29]	BUI D,BROWN H E,HARRIS R B,et al.Serologic evidence for fecal-oral transmission of Helicobacter pylori[J]. Am J Trop Med Hyg,2015,94(1):82-88.
[30]	CHEN L K,HWANG S J,WU T C,et al.Helicobacter pylori and hepatitis a virus infection in school-aged children on two isolated neighborhood islands in Taiwan[J]. Helicobacter,2010,8(3):168-172.
[31]	HOOI J K Y,LAI W Y,NG W K,et al. Global prevalence of Helicobacter pylori infection:systematic review and meta-analysis[J]. Gastroenterology,2017,153(2):420-429.
[32]	ABEBAW W,KIBRET M,ABERA B.Prevalence and risk factors of H. pylori from dyspeptic patients in northwest Ethiopia:a hospital based cross-sectional study[J]. Asian Pac J Cancer Prev,2014,15(11):4459-4463.
[33]	ŁASZEWICZ W,IWAŃCZAK F,IWAŃCZAK B. Seroprevalence of Helicobacter pylori infection in Polish children and adults depending on socioeconomic status and living conditions[J]. Adv Med Sci,2014,59(1):147-150.
[34]	SINGH S,JHA H C.Status of Epstein-Barr virus coinfection with Helicobacter pylori in gastric cancer[J]. J Oncol,2017,2017:3456264.
[35]	KRUEGER W S,HILBORN E D,CONVERSE R R,et al.Environmental risk factors associated with Helicobacter pylori seroprevalence in the United States:a cross-sectional analysis of NHANES data[J]. Epidemiol Infect,2015,143(12):2520-2531.
[36]	ELNAZ S,AMIRHOSSEIN S. vacA genotype status of Helicobacter pylori isolated from foods with animal origin[J]. Biomed Res Int,2016,2016:8701067.
[37]	MOMTAZ H,DABIRI H,SOUOD N,et al.Study of Helicobacter pylori genotype status in cows,sheep,goats and human beings[J]. BMC Gastroenterol,2014,14:61.
[38]	TURUTOGLU H,MUDUL S.Investigation of Helicobacter pylori in raw sheep milk samples[J]. J Vet Med B Infect Dis Vet Public Health,2002,49(6):308-309.
[39]	GUO L,YIN R,XU G,et al.Immunologic properties and therapeutic efficacy of a multivalent epitope-based vaccine against four Helicobacter pylori adhesins(urease,Lpp20,HpaA,and CagL) in Mongolian gerbils[J]. Helicobacter,2017,22(6):10.
[40]	LERTSETHTAKARN P,OTTEMANN K M,HENDRIXSON D R.Motility and chemotaxis in Campylobacter and Helicobacter[J]. Ann Rev Microbiol,2011,65:389-410.
[41]	ZHANG H,LAM K H,LAM W W L,et al. A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori[J]. Mol Microbiol,2017,106(5):690-703.
[42]	MATOS J I,DE SOUSA H A,MARCOS-PINTO R,et al. Helicobacter pylori CagA and VacA genotypes and gastric phenotype:a meta-analysis[J]. Eur J Gastroenterol Hepatol,2013,25(12):1431-1441.
[43]	TOITA N,YOKOTA S,FUJII N,et al.Clonality analysis of Helicobacter pylori in patients isolated from several biopsy specimens and gastric juice in a Japanese urban population by random amplified polymorphic DNA fingerprinting[J]. Gastroenterol Res Pract,2013,2013:721306.
[44]	HAN S R,ZSCHAUSCH H C,MEYER H G,et al.Helicobacter pylori:clonal population structure and restricted transmission within families revealed by molecular typing[J]. J Clin Microbiol,2000,38(10):3646-3651.
[45]	KIBRIA K M,HOSSAIN M E,SULTANA J,et al.The prevalence of mixed Helicobacter pylori infections in symptomatic and asymptomatic subjects in Dhaka,Bangladesh[J]. Helicobacter,2015,20(5):397-404.
[46]	FALSAFI T,SOTOUDEH N,FEIZABADI M M,et al.Analysis of genomic diversity among Helicobacter pylori strains isolated from Iranian children by pulsed field gel electrophoresis[J]. Iran J Pediatr,2014,24(6):703-709.
[47]	KIM Y S,KIM N,KIM J M,et al.Helicobacter pylori genotyping findings from multiple cultured isolates and mucosal biopsy specimens:strain diversities of Helicobacter pylori isolates in individual hosts[J]. Eur J Gastroenterol Hepatol,2009,21(5):522-528.
[48]	WANGDA S,RICHTER J M,KUENZANG P,et al.Epidemiology of Helicobacter pylori infection in asymptomatic schoolchildren in Bhutan[J]. Helicobacter,2017,22(6):10.
[49]	MASCELLINO M T,POROWSKA B,DE ANGELIS M,et al.Antibiotic susceptibility,heteroresistance,and updated treatment strategies in Helicobacter pylori infection[J]. Drug Des Devel Ther,2017,11:2209-2220.