关键词: 病原菌, 耐药分析, 血液透析, 血流感染

Abstract:

Objective To analyze the bloodstream infection and pathogen drug resistance in hemodialysis patients in hemodialysis center retrospectively,and to provide a reference for infection control.Methods Fever patients in the hemodialysis center from January 2013 to December 2016 were enrolled. Antibiotic susceptibility test and pathogen identification were performed by Vitek 2 compact system（BioMerieux）. The results were analyzed according to the Clinical and Laboratory Standards Institute（CLSI）M100-S26. SPSS 17.0 software was used for statistical analysis.Results A total of 86 isolates of pathogens were isolated from 816 specimens（10.5%）,but there was no significant increasing or decreasing trend from 2013 to 2016（P>0.25）. Gram-positive cocci accounted for 54.7%（47/86）,and the main pathogen was Staphylococcus aureus. Gram-negative bacilli accounted for 37.2%（32/86）,and the main pathogen was Escherichia coli. Only 8.1%（7/86） isolates were fungi. All of the Gram-positive cocci were sensitive to vancomycin and linezolid,but the susceptibility to penicillin was low. All of the Gram-negative bacilli were sensitive to amikacin and meropenem,but the susceptibility to ampicillin was low. The fungi were sensitive to all of the antibiotics determined. Only 19.8%（17/86） isolates were multi-drug resistant organisms.Conclusions Dialysis scheme should base on individual status to avoid blood infection. Most of the pathogens isolated from patients in the hemodialysis center are Gram-positive cocci,and the determination rate of multi-drug resistant organisms is not high. Empirical treatment will be effective,but medication should be adjusted according to drug susceptibility results.

Key words: Pathogen, Drug resistance analysis, Hemodialysis, Bloodstream infection