关键词: 细胞因子, 精神分裂症, 辅助诊断, 临床症状

Abstract:

Objective To investigate the changes of serum interleukin（IL）-1β,IL-6,tumor necrosis factor-alpha（TNF-α）,IL-17 and IL-23 levels in schizophrenia patients,and to evaluate the roles in the auxiliary diagnosis of schizophrenia.Methods A total of 85 patients with schizophrenia were enrolled as case group,and 85 healthy subjects were enrolled as control group. IL-1β,IL-6,TNF-α,IL-17 and IL-23 were determined by enzyme-linked immunosorbent assay（ELISA）. The changes of case group before and after treatment for 3 months were evaluated. The auxiliary diagnosis role of serum cytokines was evaluated by receiver operating characteristic（ROC） curve. Pearson correlation analysis was used to analyze the correlation between the levels of serum cytokines and the positive and negative syndrome scale（PANSS） score.Results Before treatment,serum levels of IL-1β,IL-6,TNF-α,IL-17 and IL-23 in case group were higher than those in control group（P<0.01）. After treatment for 3 months,serum levels of IL-1β,IL-6,TNF-α,IL-17 and IL-23 in case group were lower than those before treatment（P<0.01）,and there was no statistical significance compared with control group（P>0.05）. The areas under ROC curves（AUC） of serum IL-1β,IL-6,TNF-α,IL-17 and IL-23 were 0.723,0.772,0.686,0.685 and 0.679. Serum IL-1β,IL-17 and IL-23 were positively correlated with PANSS total score,positive symptom score,general psychopathology score and supplemental aggression risk subscale score TNF-α was positively correlated with positive symptom score（P<0.05）,and IL-6 was positively correlated with PANSS total score and negative symptom score（P<0.05）.Conclusions The activation of serum cytokines（IL-1β,IL-6,TNF-α,IL-17 and IL-23） exists in schizophrenia patients,serum cytokines play roles in the auxiliary diagnosis of schizophrenia,and these levels are correlated with clinical symptoms.

Key words: Cytokine, Schizophrenia, Auxiliary diagnosis, Clinical symptom