精神分裂症患者血清D-乳酸、二胺氧化酶、内毒素的变化

doi:10.3969/j.issn.1673-8640.2021.010.010

摘要/Abstract

摘要：

目的探讨血清二胺氧化酶、D-乳酸及内毒素在精神分裂症患者肠道屏障损伤评估中的作用。方法选取精神分裂症患者296例（精神分裂症组）、体检健康者99名（正常对照组）,检测血清二胺氧化酶、D-乳酸及内毒素水平。将296例精神分裂症患者按年龄（≤51岁、>51岁）和性别分别分组。结果精神分裂症组血清二胺氧化酶、D-乳酸及内毒素水平均高于正常对照组（P<0.05）。精神分裂症组≤51岁者与>51岁者之间、男性与女性之间血清二胺氧化酶、D-乳酸及内毒素水平差异均无统计学意义（P>0.05）。结论血清二胺氧化酶、D-乳酸和内毒素可作为评估精神分裂症患者肠道屏障功能的指标。

关键词: 二胺氧化酶, D-乳酸, 细菌内毒素, 精神分裂症

Abstract:

Objective To investigate the roles of serum diamine oxidase,D-lactic acid and endotoxin in the assessment of intestinal barrier injury in patients with schizophrenia. Methods A total of 296 schizophrenia patients and 99 healthy subjects were enrolled,and serum diamine oxidase,D-lactic acid and endotoxin levels were determined. The 296 schizophrenia patients were classified according to ages（≤51-year-old and >51-year-old groups） and sex. Results The levels of serum diamine oxidase,D-lactic acid and endotoxin in schizophrenia group were higher than those in healthy control group（P<0.05）. There was no statistical significance in serum diamine oxidase,D-lactic acid and endotoxin between ≤51-year-old and >51-year-old groups and between males and females（P>0.05）. Conclusions Serum diamine oxidase,D-lactic acid and endotoxin can be used to assess the intestinal barrier function in patients with schizophrenia.

Key words: Diamine oxidase, D-lactic acid, Endotoxin, Schizophrenia

中图分类号:

Q554

金伟峰, 李萍, 陈姝子, 孙佳琪, 方伟, 李丹, 朱丽萍, 朱莉莉, 林萍. 精神分裂症患者血清D-乳酸、二胺氧化酶、内毒素的变化[J]. 检验医学, 2021, 36(10): 1039-1041.

JIN Weifeng, LI Ping, CHEN Shuzi, SUN Jiaqi, FANG Wei, LI Dan, ZHU Liping, ZHU Lili, LIN Ping. Changes of serum diamine oxidase,D-lactic acid and endotoxin in patients with schizophrenia[J]. Laboratory Medicine, 2021, 36(10): 1039-1041.

图/表 3

参考文献 17

[1]	GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global,regional,and national incidence,prevalence,and years lived with disability for 354 diseases and injuries for 195 countries and territories,1990-2017:a systematic analysis for the Global Burden of Disease Study 2017BD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global,regional,and national incidence,prevalence,and years lived with disability for 354 diseases and injuries for 195 countries and territories,1990-2017:a systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet, 2018, 392(10159):1789-1858. DOI URL
[2]	IKEDA M, MUSHIRODA T. The genetics of antipsychotic response in schizophrenia[J]. Lancet Psychiatry, 2018, 5(4):291-292. DOI URL
[3]	STILO S A, MURRAY R M. Non-genetic factors in schizophrenia[J]. Curr Psychiatry Rep, 2019, 21(10):100. DOI URL
[4]	DINAN T G, CRYAN J F, STANTON C. Gut microbes and brain development have black box connectivity[J]. Biol Psychiatry, 2018, 83(2):97-99. DOI URL
[5]	中华医学会精神科分会. 中国精神障碍分类与诊断标准第3版(CCMD-3)[M]. 济南: 山东科学技术出版社, 2001.
[6]	RHEE S H, POTHOULAKIS C, MAYER E A. Principles and clinical implications of the brain-gut-enteric microbiota axis[J]. Nat Rev Gastroenterol Hepatol, 2009, 6(5):306-314. DOI URL
[7]	ROMIJN J A, CORSSMIT E P, HAVEKES L M, et al. Gut-brain axis[J]. Curr Opin Clin Nutr Metab Care, 2008, 11(4):518-521. DOI URL
[8]	SEVERANCE E G, ALAEDINI A, YANG S, et al. Gastrointestinal inflammation and associated immune activation in schizophrenia[J]. Schizophr Res, 2012, 138(1):48-53. DOI URL
[9]	FUKUDOME I, KOBAYASHI M, DABANAKA K, et al. Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats[J]. Med Mol Morphol, 2014, 47(2):100-107. DOI URL
[10]	YACOUB M R, RAMIREZ G A, BERTI A, et al. Diamine oxidase supplementation in chronic spontaneous urticaria:a randomized,double-blind placebo-controlled study[J]. Int Arch Allergy Immunol, 2018, 176(3-4):268-271. DOI URL
[11]	ASSADIAN A, ASSADIAN O, SENEKOWITSCH C, et al. Plasma D-lactate as a potential early marker for colon ischaemia after open aortic reconstruction[J]. Eur J Vasc Endovasc Surg, 2006, 31(5):470-474. DOI URL
[12]	NEMANI K, HOSSEINI GHOMI R, MCCORMICK B, et al. Schizophrenia and the gut-brain axis[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2015, 56:155-160. DOI URL
[13]	LAMBERT G P. Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects[J]. J Anim Sci, 2009, 87(14 Suppl):E101-E108. DOI URL
[14]	COLLINS S M, BERCIK P. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease[J]. Gastroenterology, 2009, 136(6):2003-2014. DOI URL
[15]	SÖDERHOLM J D, PERDUE M H. Stress and gastrointestinal tract. Ⅱ. Stress and intestinal barrier function[J]. Am J Physiol Gastrointest Liver Physiol, 2001, 280(1):G7-G13. DOI URL
[16]	SEVERANCE E G, GRESSITT K L, STALLINGS C R, et al. Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia[J]. Schizophr Res, 2013, 148(1-3):130-137. DOI URL
[17]	WILSON I D, NICHOLSON J K. Gut microbiome interactions with drug metabolism,efficacy,and toxicity[J]. Transl Res, 2017, 179:204-222. DOI URL

组别	例数	二胺氧化酶/（U/L）	D-乳酸/（mg/L）	内毒素/（U/L）
精神分裂症组	296	18.71（13.24~25.44）	29.40（23.88~38.67）	18.76（16.09~23.24）
正常对照组	99	7.70（5.00~11.23）	9.46（5.33~13.10）	5.68（1.78~9.83）
U值		4 209.5	1 425.0	1 309.0
P值		0.000	0.000	0.000

组别	例数	二胺氧化酶/（U/L）	D-乳酸/（mg/L）	内毒素/（U/L）
精神分裂症组	296	18.71（13.24~25.44）	29.40（23.88~38.67）	18.76（16.09~23.24）
正常对照组	99	7.70（5.00~11.23）	9.46（5.33~13.10）	5.68（1.78~9.83）
U值		4 209.5	1 425.0	1 309.0
P值		0.000	0.000	0.000

年龄	例数	二胺氧化酶/（U/L）	D-乳酸/（mg/L）	内毒素/（U/L）
≤51岁	150	18.05（11.76~24.71）	28.55（22.75~37.08）	18.45（15.99~23.25）
>51岁	146	19.06（13.80~26.45）	30.42（24.10~40.05）	19.14（16.31~23.27）
U值		9 800.5	10 243.5	10 398.5
P值		0.118	0.337	0.454

年龄	例数	二胺氧化酶/（U/L）	D-乳酸/（mg/L）	内毒素/（U/L）
≤51岁	150	18.05（11.76~24.71）	28.55（22.75~37.08）	18.45（15.99~23.25）
>51岁	146	19.06（13.80~26.45）	30.42（24.10~40.05）	19.14（16.31~23.27）
U值		9 800.5	10 243.5	10 398.5
P值		0.118	0.337	0.454

性别	例数	二胺氧化酶/（U/L）	D-乳酸/（mg/L）	内毒素/（U/L）
男性	160	18.71（13.22~26.20）	29.60（24.37~37.51）	18.51（16.48~22.99）
女性	136	18.55（13.33~25.09）	29.20（22.72~39.44）	19.05（15.48~23.57）
U值		10 480.0	10 859.5	10 762.0
P值		0.586	0.978	0.872