维生素D检测标准化进程

doi:10.3969/j.issn.1673-8640.2016.01.016

摘要/Abstract

摘要：

25-羟基维生素D[25（OH）D]是反映人体内维生素D状态的最佳指标,但检测方法间较大的结果差异影响了维生素D缺乏的临床诊断和治疗。临床和科研实验室检测方法的标准化是建立循证医学导则的必要基础。2010年,美国国立卫生研究院营养健康办公室（NIH-ODS）启动了维生素D标准化计划。文章介绍了国外维生素D标准化计划的一些相关进展。

关键词: 25-羟基维生素D, 标准化, 维生素D标准化计划

Abstract:

The assay of serum 25-hydroxyvitamin D [25（OH）D] concentration is the best approach to assess human vitamin D status. However,it has also been recognized that there is substantial between-assay variability which clearly confounds the diagnosis and treatment of hypovitaminosis D. Therefore,to develop and implement evidence-based clinical guidelines,it is essential that 25（OH）D determination should be standardized in both clinical and research laboratories. In 2010,the Vitamin D Standardization Program was organized by the Ofﬁce of Dietary Supplements of the National Institutes of Health （NIH-ODS）. In this review,we outline a way toward achieving the Vitamin D Standardization Program.

Key words: 25-hydroxyvitamin D, Standardization, The Vitamin D Standardization Program

中图分类号:

R446.1

周琰, 潘柏申. 维生素D检测标准化进程[J]. 检验医学, 2016, 31(1): 71-75.

ZHOU Yan, PAN Baishen. Progress of vitamin D assay standardization[J]. Laboratory Medicine, 2016, 31(1): 71-75.

图/表 2

参考文献 22

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项目	组成部分
参考测量程序	NIST：LC-MS/MS; 根特大学：LC-MS/MS
标准参考物质	NIST2972、972、972a
性能验证程序	CDC 标准化认证程序
PT/EQA	CAP、DEQAS、NIST-NIH、VitDQAP

项目	组成部分
参考测量程序	NIST：LC-MS/MS; 根特大学：LC-MS/MS
标准参考物质	NIST2972、972、972a
性能验证程序	CDC 标准化认证程序
PT/EQA	CAP、DEQAS、NIST-NIH、VitDQAP

实验室	CV	偏倚
参考实验室	≤5	≤1.7
常规检测实验室	≤10	≤5

实验室	CV	偏倚
参考实验室	≤5	≤1.7
常规检测实验室	≤10	≤5

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