Research progress on artificial intelligence in assisting diagnosis of bone marrow cell morphology

doi:10.3969/j.issn.1673-8640.2025.01.002

Abstract

Abstract:

The diagnosis of hematologic neoplasms requires comprehensive consideration of clinical manifestations，bone marrow cell morphology，genetics and immune phenotypes. However，bone marrow cell morphology examination is regarded as the gold standard for morphological diagnosis of most hematologic diseases. With the widespread application of tissue image analysis and artificial intelligence （AI） in clinical practice，the automatic image processing system developed using AI demonstrates significant advantages in the bone marrow cell morphology，which can improve the efficiency and quality of morphological diagnosis，reduce labor costs，and enhance the consistency and comparability of determination results. This review focuses on the latest progress in AI's identification of bone marrow cell morphology and its application in the diagnosis of hematologic neoplasms，as well as discusses the challenges and value that AI faces in the future clinical trials and diagnostics.

Key words: Artificial intelligence, Bone marrow, Cell morphology, Hematologic neoplasm

CLC Number:

R446.19

WANG Chi, LIU Shaomei, LI Mianyang. Research progress on artificial intelligence in assisting diagnosis of bone marrow cell morphology[J]. Laboratory Medicine, 2025, 40(1): 8-14.

Figures/Tables 1

References 52

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系统名称	公司	应用范围
DCS-1600细胞医学图像分析仪、DSS-8200玻片扫描影像系统	深圳深析智能有限公司	利用计算机软件对涂片的细胞进行分类标记和分析，快速生成细胞形态和计数报告
Morphogo系统	杭州智微信息科技有限公司	对骨髓有核细胞进行图像采集、定位、预分类和数量统计，可通过内置模板形成图文报告
Aether AI Hema骨髓涂片数位形态分析软件	中国台湾云象科技公司	自动分类计数骨髓细胞，可在5 min之内完成判读，可识别15种骨髓血液细胞
Cellsee骨髓细胞形态分析仪	无锡瑄立智能科技有限公司	基于高倍镜下高清细胞图像，采用辅助图像识别算法计数骨髓和外周血样本中的各类细胞并分类，人工审核后修改内置模板，出具图文报告；部分医院已试用于浆膜腔积液、脑脊液图像识别等

系统名称	公司	应用范围
DCS-1600细胞医学图像分析仪、DSS-8200玻片扫描影像系统	深圳深析智能有限公司	利用计算机软件对涂片的细胞进行分类标记和分析，快速生成细胞形态和计数报告
Morphogo系统	杭州智微信息科技有限公司	对骨髓有核细胞进行图像采集、定位、预分类和数量统计，可通过内置模板形成图文报告
Aether AI Hema骨髓涂片数位形态分析软件	中国台湾云象科技公司	自动分类计数骨髓细胞，可在5 min之内完成判读，可识别15种骨髓血液细胞
Cellsee骨髓细胞形态分析仪	无锡瑄立智能科技有限公司	基于高倍镜下高清细胞图像，采用辅助图像识别算法计数骨髓和外周血样本中的各类细胞并分类，人工审核后修改内置模板，出具图文报告；部分医院已试用于浆膜腔积液、脑脊液图像识别等