Abstract:

Objective To seek a functional standard for the diagnosis of glomerular hematuria with little subjectivity. Methods Firstly,feature-deformed red blood cells（ring-,target- and spore- shaped red blood cells） were determined by light microscope,and its percentage in 150 diagnosed patients after renal biopsy was analyzed. Cut-off values were classified. The sensitivity and specificity were calculated,and receiver operating characteristic （ROC） curve was drawn. The area under ROC curve（AUC） was calculated. Results There were >30% feature-deformed red blood cells in patients with glomerular hematuria,while there were <10% feature-deformed red blood cells in patients without glomerular hematuria. Taking feature-deformed red blood cells >30% as standard for the diagnosis of glomerular hematuria,the sensitivity was 84%,the specificity was 97%,and the AUC was 0.976. Meanwhile,the opportunity of processing mixed hematuria decreased. Conclusions Ring-,target- and spore-shaped red blood cells are practical for the diagnosis of glomerular hematuria.

Key words: Glomerular hematuria, Urinary red blood cell morphology, Feature deformation, Standard