Characteristic of Auer rod-like inclusions in the cytoplasm of non-myeloid neoplasm cells

doi:10.3969/j.issn.1673-8640.2019.06.010

Abstract

Abstract:

Objective To report 2 cases of Auer rod-like inclusions in the cytoplasm of non-myeloid neoplasm（acute T lymphoblastic lymphoma/leukemia and splenic lymphoma） cells. To investigate the morphological characteristics of Auer rod and Auer rod-like inclusions. Methods The 2 cases of non-myeloid neoplasm were diagnosed by morphology,immunohistochemical staining,immunophenotype and cytogenetic analysis. Literature review was performed. Auer rod-like inclusions in the cytoplasm of non-myeloid neoplasm cells were evaluated. Results The results of immunohistochemical staining and immunophenotype were compatible with lymphoid neoplasm. For the 2 cases,the morphological characteristics of Auer rod-like inclusions and Auer rod were similar,especially in 1 case of Auer rod-like inclusion appearing in lymphoblast cell,and it was difficult to distinguish Auer rod-like inclusion and Auer rod. Conclusions Auer rod is a cytological marker of myeloid neoplasm,and it is critical in myelodysplastic syndrome（MDS） classification. However,Auer rod could be infrequently found in non-myeloid neoplasm cells,so it should be carefully revaluated not only by morphology,but also by immunohistochemical staining,immunophenotype and cytogenetic analysis.

Key words: Bone marrow examination, Morphology, Auer rod, Non-myeloid neoplasm

CLC Number:

R446.1

ZHU Jianfeng, GUO Wei, PAN Baishen, WANG Beili. Characteristic of Auer rod-like inclusions in the cytoplasm of non-myeloid neoplasm cells[J]. Laboratory Medicine, 2019, 34(6): 526-529.

Figures/Tables 3

References 15

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