Laboratory Medicine ›› 2024, Vol. 39 ›› Issue (11): 1091-1096.DOI: 10.3969/j.issn.1673-8640.2024.11.011

Previous Articles     Next Articles

Prognostic roles of Lp-PLA2,HDAC3 and TAFI levels in patients with large-scale cerebral infarction

WU Shaohua, XI Junnan, LIU Liang, WU Yating, ZHANG Meng, CHEN Liwei, XUE Meng, LIU Shifu()   

  1. Neurological Intensive Care Unit,Henan University of Science and Technology Affiliated Yellow River Hospital,Huanghe Sanmenxia Hospital,Sanmenxia 472000,Henan,China
  • Received:2024-01-12 Revised:2024-06-06 Online:2024-11-30 Published:2024-11-29
  • Contact: LIU Shifu

Abstract:

Objective To evaluate the prognostic roles of lipoprotein-associated phospholipase A2(Lp-PLA2),histone deacetylase(HDAC)3 and thrombin activable fibrinolysis inhibitor (TAFI) levels in patients with large-scale cerebral infarction. Methods A total of 120 patients with large-scale cerebral infarction in Henan University of Science and Technology Affiliated Yellow River Hospital from March 2020 to March 2023 were enrolled as large-scale cerebral infarction group,and 120 healthy subjects during the same period were enrolled as control group. Lp-PLA2,HDAC3 and TAFI levels were determined by enzyme-linked immunosorbent assay. All the patients with large-scale cerebral infarction were followed up for 90 d,which included 45 patients with poor prognosis and 75 patients with good prognosis. Spearman correlation analysis was used to evaluate the relationship between Lp-PLA2,HDAC3,TAFI levels and the National Institute of Health Stroke Scale(NIHSS)score. The prognostic roles of Lp-PLA2,HDAC3 and TAFI levels in patients with large-scale cerebral infarction was analyzed by receiver operating characteristic(ROC)curve. Multivariate Logistic regression analysis was used to evaluate the factors affecting the poor prognosis of patients with large-scale cerebral infarction. Results Compared with control group,Lp-PLA2,HDAC3 and TAFI levels in large-scale cerebral infarction group were increased (P<0.001). Lp-PLA2,HDAC3 and TAFI levels were positively correlated with NIHSS score in patients with large-scale cerebral infarction(rs=0.542,0.620 and 0.597,P<0.05). Compared with good prognosis group,NIHSS score,Lp-PLA2,HDAC3 and TAFI levels in poor prognosis group were increased (P<0.001). NIHSS score,Lp-PLA2,HDAC3 and TAFI levels were the factors for poor prognosis in patients with large-scale cerebral infarction (P<0.01). The areas under curves of Lp-PLA2,HDAC3,TAFI and NIHSS score single determinations and combined determination were 0.790,0.795,0.780,0.908 and 0.964,respectively. Conclusions Lp-PLA2,HDAC3 and TAFI in patients with large-scale cerebral infarction are increased,and the Lp-PLA2,HDAC3,TAFI and NIHSS score combined determination is of certain value in evaluating the prognosis of patients with large-scale cerebral infarction.

Key words: Lipoprotein-associated phospholipase A2, Histone deacetylase 3, Thrombin activable fibrinolysis inhibitor, Large-scale cerebral infarction

CLC Number: