Abstract:

Objective To investigate the relationship between the changes of thymidine kinase-1（TK1） and inhibitor-1 of cell differentiation（ID-1） levels and curative effect in cervical cancer patients before and after neoadjuvant chemotherapy. Methods A total of 200 patients with cervical cancer treated with neoadjuvant chemotherapy were enrolled,and serum TK1 and ID-1 levels were determined before and after neoadjuvant chemotherapy. The efficiency of each index for cervical cancer was evaluated by receiver operating characteristic（ROC） curve. Results The effective rate of chemotherapy in 200 patients with cervical cancer was 56.00%. The TK1 and ID-1 levels in patients with ineffective chemotherapy after chemotherapy were higher than those before chemotherapy（P<0.05）. The TK1 and ID-1 levels in patients with effective chemotherapy after chemotherapy were lower than those before chemotherapy（P<0.05）. The TK1 and ID-1 levels in patients with effective chemotherapy after chemotherapy were lower than those in patients with ineffective chemotherapy（P<0.001）,and serum TK1 and ID-1 decline ratios in patients with effective chemotherapy were higher than those in patients with ineffective chemotherapy（P<0.001）. ROC curve analysis showed that the optimal cut-off value of TK1 decline ratio for judging the effectiveness of chemotherapy for cervical cancer was >24.0%,and the area under curve（AUC） was 0.756. The optimal cut-off value of ID-1 decline ratio for judging the effectiveness of chemotherapy for cervical cancer was >36.0%,the AUC was 0.738,and the AUC of TK1 combined with ID-1 was 0.902. Conclusions TK1 and ID-1 can be used as indexes for evaluating the efficiency of chemotherapy,and the determination of TK1 combined with ID-1 is effective.

Key words: Thymidine kinase-1, Inhibitor-1 of cell differentiation, Neoadjuvant chemotherapy, Curative effect, Cervical cancer