Abstract:

Objective To evaluate the role of pentraxin-3（PTX3） in the diagnosis of community-acquired pneumonia（CAP）. Methods A total of 70 inpatients with CAP were enrolled,which were classified into severe CAP group and mild CAP group according to their condition. Totally,70 healthy subjects were enrolled as healthy control group. The results of C-reactive protein（CRP）,procalcitonin（PCT）,white blood cell（WBC） count and neutrophil/lymphocyte ratio（NLR） determinations were collected. Peripheral blood was collected within 24 h,on the 3rd day and the 7th day after admission,and serum PTX3 level was dynamically monitored. The correlation between different groups was compared,and the expression differences and dynamic changes of PTX3 were analyzed. Results PTX3,PCT and CRP in CAP group were higher than those in healthy control group（P<0.05）. Compared with mild CAP group,the increase of PTX3,PCT and CRP had statistical significance in severe CAP group（P<0.05）. The area under receiver operating characteristic（ROC） curve of PTX3 was 0.714,the sensitivity was 75.82%,and the specificity was 77.18%,when the cut-off value was 31.28 ng/mL. Dynamic monitoring of PTX3 showed that PTX3 level in severe CAP group was higher than that in mild CAP group（P<0.05）,and PTX3 levels in both groups gradually decreased with treatment time,but the PTX3 level in severe CAP patients remained at a high level on the 7th day. The main pathogen for CAP was bacteria,and there was no statistical significance in PTX3 level among the patients infected with different pathogens（P=0.296）. Conclusions Serum PTX3 level,especially the dynamic monitoring result,can be used as a biomarker for reflecting CAP,which can provide effective auxiliary diagnosis and efficacy monitoring for clinical practice.

Key words: Pentraxin-3, Community-acquired pneumonia, Dynamic monitoring, Clinical diagnosis, Severe pneumonia, Curative effect evaluation