Abstract:

Objective To investigate serum 25-hydroxyvitamin D level and its clinical significance in community-acquired pneumonia（CAP） children. Methods　The level of serum 25-hydroxyvitamin D and C-reactive protein（CRP） were determined in 66 children with CAP and 52 healthy subjects（healthy control group）by electrochemiluminescence immunoassay and turbidimetry immunoassay. The children were classified into mild symptom group and intensive symptom group according to the severity of CAP. Results　The level of serum 25-hydroxyvitamin D in CAP group[（27.05±10.93） μg/L] was obviously lower than that in healthy control group[（32.77±9.78） μg/L]（P＜0.01）. However， CRP in CAP group [（11.77 ±5.98） mg/L] was higher than that in healthy control group [（4.56 ±2.48） mg/L]（P＜0.01）. Meanwhile， the level of serum 25-hydroxyvitamin D in intensive symptom group was lower than that in mild symptom group， and the average age in intensive symptom group was elder than that in mild symptom group（P＜0.01）， but there was no statistical significance for CRP between the 2 groups（P＞0.05）. Conclusions　The lack of serum 25-hydroxyvitamin D may be the potential role for CAP in children， and there also is a certain significance in judging the severity of disease.

Key words: 25-hydroxyvitamin D, C-reactive protein, Community-acquired pneumonia, Child