Application progress of heparin-binding protein in infectious diseases

doi:10.3969/j.issn.1673-8640.2021.11.019

Abstract

Abstract:

The clinically commonly used auxiliary diagnostic indicators for infectious diseases include white blood cell（WBC） count,neutrophil,C-reactive protein（CRP）,procalcitonin（PCT）,erythrocyte sedimentation rate（ESR） and interleukin 6（IL-6）. However,these indicators all have the defects of low accuracy,insufficient sensitivity and poor specificity to various degrees. In the prevention and treatment of infectious diseases,how to take reasonable response measures as soon as possible is the key to successful treatment. In the recent years,with the continuous in-depth study of heparin-binding protein（HBP）,its role in the early diagnosis of infectious diseases has gradually been revealed. This review focuses on the clinical value of HBP in infectious diseases.

Key words: Heparin-binding protein, Infectious disease, Clinical diagnosis

CLC Number:

R446.1

ZHANG Wanqian, WANG Xiangfu, REN Youliang, ZHENG Huihui. Application progress of heparin-binding protein in infectious diseases[J]. Laboratory Medicine, 2021, 36(11): 1186-1189.

References 34

[1]	LINDER A, LEE T, FISHER J, et al. Short-term organ dysfunction is associated with long-term(10-yr) mortality of septic shock[J]. Crit Care Med, 2016, 44(8):e728-e736. DOI URL
[2]	中华医学会重症医学分会. 中国严重脓毒症/脓毒性休克治疗指南(2014)[J]. 中华内科杂志, 2015, 54(6):557-581.
[3]	SHAFER W M, MARTIN L E, SPITZNAGEL J K. Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diiso-propyl fluorophosphate[J]. Infect Immun, 1984, 45(1):29-35. DOI URL
[4]	GABAY J E, SCOTT R W, CAMPANELLI D, et al. Antibiotic proteins of human polymorphonuclear leukocytes[J]. Proceedings of the National Academy of Sciences, 1989, 86(14):5610-5614. DOI URL
[5]	FLODGAARD H, OSTERGAARD E, BAYNE S, et al. Covalent structure of two novel neutrophile leucocyte- derived proteins of porcine andhuman origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities[J]. Eur J Biochem, 1991, 197(2):535-547. DOI URL
[6]	GAUTAM N, OLOFSSON A M, HERWALD H, et al. Heparin-binding protein(HBP/CAP37):a missing link in neutrophil-evoked alteration of vascular permeability[J]. Nat Med, 2001, 7(10):1123-1127. DOI URL
[7]	CAI R, LI H, TAO Z. Heparin-binding protein and procalcitonin in the diagnosis of pathogens causing community-acquired pneumonia in adult patients:a retrospective study[J]. PeerJ, 2021, 9:e11056. DOI URL
[8]	TAPPER H, KARLSSON A, MÖRGELIN M, et al. Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles[J]. Blood, 2002, 99(5):1785-1793. DOI URL
[9]	何兴凤, 伍国胜, 罗鹏飞, 等. 脓毒症血管通透性分子调控机制研究进展[J]. 中华烧伤杂志, 2020, 36(10):982-986.
[10]	LIU Y, MA S, WANG X, et al. The role of β2 integrin associated heparin-binding protein release in ARDS[J]. Life Sci, 2018, 203:92-98. DOI URL
[11]	FISHER J, RUSSELL J A, BENTZER P, et al. Heparin-binding protein(HBP):a causative marker and potential target for heparin treatment of human sepsis-induced acute kidney injury[J]. Shock, 2017, 48(3):313-320. DOI URL
[12]	TYDÉN J, HERWALD H, HULTIN M, et al. Heparin-binding protein as a biomarker of acute kidney injury in critical illness[J]. Acta Anaesthesiol Scand, 2017, 61(7):797-803. DOI URL
[13]	STOCK A J, KASUS-JACOBI A, PEREIRA H A. The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease[J]. J Neuroinflammation, 2018, 15(1):240. DOI URL
[14]	STJÄRNE ASPELUND A, HAMMARSTRÖM H, INGHAMMAR M, et al. Heparin-binding protein,lysozyme,and inflammatory cytokines in bronchoalveolar lavage fluid as diagnostic tools for pulmonary infection in lung transplanted patients[J]. Am J Transplant, 2018, 18(2):444-452. DOI URL
[15]	LIN Q, SHEN J, SHEN L, et al. Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome[J]. Crit Care, 2013, 17(4):R155. DOI URL
[16]	万东文. 3种指标联合检测在急性重症胰腺炎继发感染诊断中的应用研究[J]. 河南医学研究, 2017, 26(9):1630-1631.
[17]	邱飞, 钟小妹, 高丹, 等. 肝素结合蛋白与降钙素原在重症胰腺炎继发细菌感染患者中的诊断价值[J]. 中国卫生检验杂志, 2019, 29(7):807-809.
[18]	陈若虹, 胡敏, 任亚萍, 等. 脑脊液肝素结合蛋白和降钙素原在细菌性颅内感染诊断中的应用[J]. 临床检验杂志, 2016, 34(4):256-259.
[19]	KANDIL M, KHALIL G, EL-ATTAR E, et al. Accuracy of heparin binding protein:as a new marker in prediction of acute bacterial meningitis[J]. Braz J Microbiol, 2018, 49(Suppl 1):213-219. DOI URL
[20]	王迪, 金磊, 陈锟, 等. 尿液肝素结合蛋白浓度在尿路感染中的临床诊断价值[J]. 中华检验医学杂志, 2017, 40(12):953-958.
[21]	KJÖLVMARK C, PÅHLMAN L I, ÅKESSON P, et al. Heparin-binding protein:a diagnostic biomarker of urinary tract infection in adults[J]. Open Forum Infect Dis, 2014, 1(1):ofu004.
[22]	王卓, 纪卫华, 王雨新, 等. 肝素结合蛋白在新生儿早期细菌感染性疾病诊断中的应用价值[J]. 中华检验医学杂志, 2016, 39(12):972-973.
[23]	ZANFALY H E, SHALAB S M, ELSHAL A S. Heparin-binding protein as a predictive and diagnostic biomarker for severe sepsis and septic shock in patients with sepsis[J]. Research and Opinion in Anesthesia and Intensive Care, 2016, 3(3):95-102. DOI URL
[24]	LI W Q, CHEN Y, LIU T J, et al. Serum procalcitonin,white blood cell and hypersensitive C-reactive protein combined with age established a new prediction model in predicting ICU admission in adult community-acquired pneumonia(CAP) patients[J]. Clin Lab, 2020, 66(5).
[25]	PRESNYAKOVA M V, GALOVA E A, SOSNINA L N, et al. Disturbances of the hemostasis system and expression of inflammatory reaction in patients with new coronaviral pneumonia[J]. Klin Lab Diagn, 2020, 65(12):744-749. DOI URL
[26]	QUADIR A F, BRITTON P N. Procalcitonin and C-reactive protein as biomarkers for neonatal bacterial infection[J]. J Paediatr Child Health, 2018, 54(6):695-699. DOI URL
[27]	STANOJCIC M, VINAIK R, JESCHKE M G. Status and challenges of predicting and diagnosing sepsis in burn patients[J]. Surg Infect(Larchmt), 2018, 19(2):168-175.
[28]	吴苑, 喻丹, 王海, 等. 肝素结合蛋白与降钙素原和 C 反应蛋白及白细胞计数对呼吸道局部细菌感染诊断的应用价值[J]. 中华检验医学杂志, 2017, 40(9):711-715.
[29]	夏莹, 王颖, 何怀武, 等. 白细胞、降钙素原和超敏C反应蛋白在超高龄重症患者血流感染的诊断预测价值[J]. 中华医学杂志, 2019, 99(5):365-369.
[30]	任继欣, 郭彦言. 外周血HBP,IL-6,CD64指数,PCT,CRP和SAA水平检测在血流感染诊断中的应用价值研究[J]. 现代检验医学杂志, 2020, 35(2):56-59.
[31]	HALE A J, RICOTTA D N, FREED J A. Evaluating the erythrocyte sedimentation rate[J]. JAMA, 2019, 321(14):1404-1405. DOI URL
[32]	ROSE-JOJN S. Interleukin-6 family cytokines[J]. Cold Spring Harb Perspect Biol, 2018, 10(2):a028415. DOI URL
[33]	徐冬梅, 季孝, 周雪芬, 等. 白细胞介素-6、血清淀粉样A蛋白、唾液酸、HBP在发热患者中的诊断价值[J]. 中国卫生检验杂志, 2019, 29(24):3027-3029.
[34]	张国辉. 血液HBP,CRP和WBC联合检测对儿童脓毒血症早期诊断价值研究[J]. 现代检验医学杂志, 2018, 33(4):107-111.