Abstract:

Objective To investigate the relations of C-reactive protein（CRP）,neutrophil,eosinophil,neutrophil-to-lymphocyte ratio（NRL）,cholinesterase,albumin（Alb） and vitamin D with the long-term mortality in patients with chronic obstructive pulmonary disease（COPD）. Methods A total of 120 COPD patients in Luoding People's Hospital from January 2015 to January 2017 were enrolled and followed up for 24 months. The subjects were classified into long-term death group（17 cases） and survival group（89 cases）. The levels of CRP,neutrophil,eosinophil,NRL,cholinesterase,Alb and 25-hydroxyvitamin D [25（OH）D]（vitamin D） between the 2 groups were compared. Logistic analysis was used to evaluate the relations between the blood indicators and long-term mortality,and the predictive value of the blood indicators was analyzed by receiver operating characteristic（ROC） curve analysis. Results The levels of CRP,neutrophil,eosinophil and NRL in long-term death group were higher than those in survival group（P<0.05）,and the cholinesterase,Alb and 25（OH）D levels were lower than those in survival group（P<0.05）. CRP,neutrophil,eosinophil,NRL,cholinesterase,25（OH）D and Alb were independent risk factors for predicting long-term mortality in COPD patients（odds ratios were 1.23,0.99,1.45,2.75,1.30,1.08 and 0.59,respectively）（P<0.05）. The sensitivities and specificities of the 7 indicators had no statistical significance（P>0.05）,and the area under curve（AUC） of NRL was bigger than those of the other 6 indicators（P<0.05）. Conclusions CRP,neutrophil,eosinophil,NRL,cholinesterase,Alb and 25（OH）D have positive significance in predicting the long-term mortality of COPD,and NRL is a significant predictive indicator.

Key words: Chronic obstructive pulmonary disease, Blood indicator, Long-term mortality