Abstract:

Objective To determine the level changes of serum cholyglycine（CG） and C-reactive protein（CRP） in patients with chronic obstructive pulmonary disease（COPD）,and to investigate the correlations with the altering of lung and liver function.Methods A total of 64 patients with COPD were enrolled and classified into acute exacerbation of chronic obstructive pulmonary disease（AECOPD） group（46 cases,including 32 cases with liver damage and 14 cases without liver damage） and stable COPD group（18 cases）. A total of 27 healthy subjects were enrolled as healthy control group. The levels of serum CG and CRP were determined before and after treatment. Alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,total bilirubin（TB）,direct bilirubin（DBil）and albumin（Alb） in COPD group were determined before treatment.Results Serum CG and CRP in COPD group were higher than those in healthy control group（P<0.05）. In AECOPD group,serum CG and CRP were higher than those in stable COPD group（P<0.05）. In AECOPD with liver damage group,serum CG and CRP were higher than those in AECOPD without liver damage group（P<0.05）. The positive rates of serum CG and CRP in COPD group before treatment were 82.8% and 85.9%,and those after treatment were 28.1% and 21.9%（P<0.05）. The levels of ALT,AST and serum CG in AECOPD with liver damage group were higher than those in AECOPD without liver damage group and stable COPD group（P<0.01）. The levels of ALT and serum CG in AECOPD group without liver damage were higher than those in stable COPD group（P<0.05）. The levels of TB,DBil and Alb in AECOPD with and without liver damage groups had no statistical significance（P>0.05）. The positive rate of serum CG was the highest,followed by those of ALT and AST. There was a positive correlation of serum CG with ALT,AST and CRP（r=0.653,0.532 and 0.783,P<0.01）, but there was no correlation with Alb,TB and DBil（r= 0.208,0.252 and 0.267,P>0.05）. Conclusions Serum CG and CRP are involved in acute inflammatory process of COPD. For patients with COPD,there exists lung damage,while there are different degrees of liver damage.

Key words: Cholyglycine, C-reactive protein, Chronic obstructive pulmonary disease, Liver damage