Abstract:

Objective　To investigate the infection status of human papilloma virus（HPV） in women with different ages， and to provide the theory reference for preventing
and treating cervical cancer. Methods　Totally 3 426 samples of cervical secretions were determined for HPV DNA subtypes by multi-channel real-time fluorescence quantitation polymerase chain reaction（PCR）. HPV DNA subtypes included 8 high risk types（HPV16， 18， 45， 31， 33， 52， 58 and 67）. The infection status of HPV in women with different ages was analyzed. Results　The 583 samples among the 3 426 cases were HPV positive， and the positive rate was 17.02%. HPV infection mainly distributed among women with 19-40 years old. In women with 19-30 years old， the HPV positive rate was 20.37%， which was higher than
those with other ages（P＜0.05）. There were subtype infection and multi-subtype infection. The most common subtypes were HPV33/52/58/67（59.01%）， HPV16（14.92%） and HPV18/45（9.43%）. Conclusions　The 19-30 years old is the peak period of HPV infection， but the HPV infection rate in middle aged and elder women is still high， and there is an increasing trend in young women. The most common HPV infection genotypes were HPV33/52/58/67， HPV16 and HPV18/45 with the population distribution characteristic of HPV genotype among women.

Key words: Human papilloma virus, Cervical cancer, Subtype, Age