Role of NGAL for the diagnosis of kidney injury in patients with essential hypertension

doi:10.3969/j.issn.1673-8640.2019.05.002

Abstract

Abstract:

Objective To investigate the role of neutrophil gelatinase-associated lipocalin （NGAL） for the diagnosis of kidney injury in patients with essential hypertension. Methods A total of 154 patients with essential hypertension [stage 1 group （50 cases）,stage 2 group （47 cases） and stage 3 group （57 cases）] and 50 healthy subjects （healthy control group） were determined for the levels of serum creatinine （Cr）,cystatin C（Cys C）and NGAL. Receiver operating characteristic （ROC） curve was used to evaluate the roles of Cys C and NGAL for the diagnosis of kidney injury in patients with essential hypertension. Pearson correlation analysis was used to evaluate the correlations between variables. Results The levels of serum Cr,Cys C and NGAL in essential hypertension group were higher than those in healthy control group （P<0.05）. The estimated glomerular filtration rate（eGFR） in healthy control group was higher than those in stage 3 and 2 groups （P<0.05）. Serum NGAL,Cr and Cys C levels in stage 3 group were higher than those in stage 2 and 1 groups （P<0.05,P<0.001）. Serum NGAL level in stage 2 group was higher than that in stage 1 group （P<0.001）. The eGFR in stage 3 group was lower than those in stage 1 and 2 groups （P<0.05）. There was a strong positive correlation between serum Cr and Cys C（r=0.789,P<0.001）,but serum NGAL had a weak positive correlation with Cr（r=0.314,P<0.001）and Cys C（r=0.333,P<0.001）. The combined determination of Cys C and NGAL for the diagnosis of kidney injury in patients with essential hypertension had the area under curve（AUC） of 0.935,which was bigger than those of single determinations （that for NGAL was 0.874 and that for Cys C was 0.910）. The positive rate of combined determination （78.6%） was higher than those of Cys C and NGAL single determinations （51.2% and 69.4%,respectively,P<0.001）. Conclusions NGAL plays a role in the diagnosis of kidney injury for patients with essential hypertension.

Key words: Neutrophil gelatinase-associated lipocalin, Kidney injury, Essential hypertension

CLC Number:

R446.1

LI Bo, WANG Haiyu, LIU Yajie. Role of NGAL for the diagnosis of kidney injury in patients with essential hypertension[J]. Laboratory Medicine, 2019, 34(5): 390-393.

Figures/Tables 2

References 12

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组别	例数	Cr（μmol/L）	Cys C（mg/L）	NGAL（ng/mL）	eGFR[mL/（min·1.73 m²）]
正常对照组	50	61.00（52.00~73.00）	0.67 （0.64~0.76）	68.85 （54.15~89.25）	92.86 （81.75~103.96）
原发性高血压组
1级高血压组	50	69.45（59.62~81.87）^*	0.93 （0.81~1.08）^*	103.90（59.47~182.82）^*	89.72 （76.33~97.75）
2级高血压组	47	77.40（58.50~89.80）^*	1.05 （0.88~1.16）^*	195.90（148.80~254.10）^*#	84.14 （72.42~92.33）^*
3级高血压组	57	81.30（70.70~107.50）^*#△	1.14 （0.96~1.37）^*#△	233.00（168.85~333.45）^*#△	72.42 （52.04~89.87）^*#△

组别	例数	Cr（μmol/L）	Cys C（mg/L）	NGAL（ng/mL）	eGFR[mL/（min·1.73 m²）]
正常对照组	50	61.00（52.00~73.00）	0.67 （0.64~0.76）	68.85 （54.15~89.25）	92.86 （81.75~103.96）
原发性高血压组
1级高血压组	50	69.45（59.62~81.87）^*	0.93 （0.81~1.08）^*	103.90（59.47~182.82）^*	89.72 （76.33~97.75）
2级高血压组	47	77.40（58.50~89.80）^*	1.05 （0.88~1.16）^*	195.90（148.80~254.10）^*#	84.14 （72.42~92.33）^*
3级高血压组	57	81.30（70.70~107.50）^*#△	1.14 （0.96~1.37）^*#△	233.00（168.85~333.45）^*#△	72.42 （52.04~89.87）^*#△

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