Clinical experimental research progress of primary glaucoma pathogenesis

doi:10.3969/j.issn.1673-8640.2019.01.015

Abstract

Abstract:

Glaucoma is a leading cause of irreversible vision loss in the world. Because it may be asymptomatic until the patients are at a relatively late stage and undergo characteristic glaucomatous optic neuropathy,the diagnosis is frequently delayed. Although the pathogenesis of primary glaucoma is complex and diverse,several important pathomechanisms related to primary glaucoma have been discovered,involving mechanical compression,vascular structural and functional damage,oxidative stress,inflammation and immune dysregulation. The research of the key pathways and molecules has made progress. Clinical experimental studies have also identified many candidate biomarker clusters that are potential targets for clinical diagnosis and treatment through further research. This review focuses on the progress of clinical experimental research in the pathogenesis of primary glaucoma to provide a reference for further clinical studies.

Key words: Primary glaucoma, Pathogenesis, Clinical experimental research, Biomarker

CLC Number:

R775.1

MA Yi, CAO Wenjun, SUN Xinghuai. Clinical experimental research progress of primary glaucoma pathogenesis[J]. Laboratory Medicine, 2019, 34(1): 71-75.

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