Laboratory Medicine ›› 2022, Vol. 37 ›› Issue (8): 782-786.DOI: 10.3969/j.issn.1673-8640.2022.08.015
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WU Yanqian1, YU Chong2, SHEN Lu3, ZHENG Haoran1, HONG Yeting1()
Received:
2022-01-12
Revised:
2022-06-08
Online:
2022-08-30
Published:
2022-09-16
Contact:
HONG Yeting
CLC Number:
WU Yanqian, YU Chong, SHEN Lu, ZHENG Haoran, HONG Yeting. Research progress of body fluid piRNA as a potential biomarker of disease[J]. Laboratory Medicine, 2022, 37(8): 782-786.
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URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2022.08.015
样本类型 | piRNA | 疾病 | 表达量 | 临床分析 |
---|---|---|---|---|
外周血 | piR-651、piR-823 | 胃癌 | 降低 | TNM分期和远隔转移 |
外周血 | piR-5937、piR-28876 | 结直肠癌 | 降低 | 诊断、TNM分期 |
外周血 | piR-017724 | 结直肠癌 | 降低 | 诊断和预后 |
外周血 | piR-54265 | 结直肠癌 | 升高 | 筛查、早期检测和临床监测 |
外周血 | piR-020619、piR-020450 | 结直肠癌 | 升高 | 早期检测 |
外周血 | piR-823 | 结直肠癌 | 升高 | 诊断TNM分期 |
外周血 | piR-10506469、piR-20548188 | 胆管癌和胆囊癌 | 升高 | 诊断和预后 |
外周血 | piR-651 | 霍奇金淋巴瘤 | 降低 | 评估生存期和预后 |
外周血 | piR-823 | 多发性骨髓瘤 | 升高 | 诊断、分期和预后 |
外周血 | piR-020009、piR-006426 | 心力衰竭 | 降低 | 诊断 |
外周血 | piR-012753、piR-016735 | 慢性阻塞性肺疾病 | 升高 | 区分慢性阻塞性肺疾病患者与吸烟者、非吸烟者 |
外周血 | piR-009228、piR-016659、piR-020496 | 非综合征型唇腭裂 | 升高 | 产前筛查畸形儿 |
外周血 | piR-5936 | 膀胱癌 | 升高 | 膀胱癌风险等级评估 |
外周血 | piR-26399 | 男性不育 | 升高 | 诊断 |
精浆 | piR-1207、piR-2107 | 弱精症 | 降低 | 诊断 |
精浆 | piR-61927 | 非梗阻性无精症 | 降低 | 睾丸显微取精术结果评估 |
尿液 | piR-823 | 肾细胞肾癌 | 升高 | 诊断 |
尿液 | piR-018849、piR-019324 | 前列腺疾病 | 降低 | 鉴别前列腺增生和前列腺癌 |
骨髓上清液 | piR-004800 | 多发性骨髓瘤 | 升高 | 多发性骨髓瘤分期 |
样本类型 | piRNA | 疾病 | 表达量 | 临床分析 |
---|---|---|---|---|
外周血 | piR-651、piR-823 | 胃癌 | 降低 | TNM分期和远隔转移 |
外周血 | piR-5937、piR-28876 | 结直肠癌 | 降低 | 诊断、TNM分期 |
外周血 | piR-017724 | 结直肠癌 | 降低 | 诊断和预后 |
外周血 | piR-54265 | 结直肠癌 | 升高 | 筛查、早期检测和临床监测 |
外周血 | piR-020619、piR-020450 | 结直肠癌 | 升高 | 早期检测 |
外周血 | piR-823 | 结直肠癌 | 升高 | 诊断TNM分期 |
外周血 | piR-10506469、piR-20548188 | 胆管癌和胆囊癌 | 升高 | 诊断和预后 |
外周血 | piR-651 | 霍奇金淋巴瘤 | 降低 | 评估生存期和预后 |
外周血 | piR-823 | 多发性骨髓瘤 | 升高 | 诊断、分期和预后 |
外周血 | piR-020009、piR-006426 | 心力衰竭 | 降低 | 诊断 |
外周血 | piR-012753、piR-016735 | 慢性阻塞性肺疾病 | 升高 | 区分慢性阻塞性肺疾病患者与吸烟者、非吸烟者 |
外周血 | piR-009228、piR-016659、piR-020496 | 非综合征型唇腭裂 | 升高 | 产前筛查畸形儿 |
外周血 | piR-5936 | 膀胱癌 | 升高 | 膀胱癌风险等级评估 |
外周血 | piR-26399 | 男性不育 | 升高 | 诊断 |
精浆 | piR-1207、piR-2107 | 弱精症 | 降低 | 诊断 |
精浆 | piR-61927 | 非梗阻性无精症 | 降低 | 睾丸显微取精术结果评估 |
尿液 | piR-823 | 肾细胞肾癌 | 升高 | 诊断 |
尿液 | piR-018849、piR-019324 | 前列腺疾病 | 降低 | 鉴别前列腺增生和前列腺癌 |
骨髓上清液 | piR-004800 | 多发性骨髓瘤 | 升高 | 多发性骨髓瘤分期 |
[1] |
ARAVIN A, GAIDATZIS D, PFEFFER S, et al. A novel class of small RNAs bind to MILI protein in mouse testes[J]. Nature, 2006, 442(7099):203-207.
DOI URL |
[2] |
GIRARD A, SACHIDANANDAM R, HANNON G J, et al. A germline-specific class of small RNAs binds mammalian Piwi proteins[J]. Nature, 2006, 442(7099):199-202.
DOI URL |
[3] |
KIRINO Y, MOURELATOS Z. Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini[J]. Nat Struct Mol Biol, 2007, 14(4):347-348.
DOI URL |
[4] | OZATA D M, GAINETDINOV I, ZOCH A, et al. PIWI-interacting RNAs:small RNAs with big functions[J]. Nat Rev Genet, 2019, 20(2):89-108. |
[5] | 石硕, 王晨, 林海帆. PIWI/piRNA在癌症中的功能和机制[J]. 自然杂志, 2021, 43(5):313-322. |
[6] | 沈鹭, 俞翀, 高方, 等. PIWI/piRNA复合体调控精子发生的研究进展[J]. 中华男科学杂志, 2021, 27(3):262-268. |
[7] |
HUANG X, YUAN T, TSCHANNEN M, et al. Characterization of human plasma-derived exosomal RNAs by deep sequencing[J]. BMC Genomics, 2013, 14:319.
DOI URL |
[8] |
FREEDMAN J E, GERSTEIN M, MICK E, et al. Diverse human extracellular RNAs are widely detected in human plasma[J]. Nat Commun, 2016, 7:11106.
DOI URL |
[9] |
YUAN T, HUANG X, WOODCOCK M, et al. Plasma extracellular RNA profiles in healthy and cancer patients[J]. Sci Rep, 2016, 6:19413.
DOI URL |
[10] |
BAHN J H, ZHANG Q, LI F, et al. The landscape of microRNA,Piwi-interacting RNA,and circular RNA in human saliva[J]. Clin Chem, 2015, 61(1):221-230.
DOI URL |
[11] |
HONG Y, WANG C, FU Z, et al. Systematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility[J]. Sci Rep, 2016, 6:24229.
DOI URL |
[12] |
EL-MOGY M, LAM B, HAJ-AHMAD T A, et al. Diversity and signature of small RNA in different bodily fluids using next generation sequencing[J]. BMC Genomics, 2018, 19(1):408.
DOI URL |
[13] | HONG Y, WU Y, ZHANG J, et al. Decreased piRNAs in infertile semen are related to downregulation of sperm MitoPLD expression[J]. Front Endocrinol(Lausanne), 2021, 12:696121. |
[14] |
CUI L, LOU Y, ZHANG X, et al. Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as markers[J]. Clin Biochem, 2011, 44(13):1050-1057.
DOI URL |
[15] | GU X, WANG C, DENG H, et al. Exosomal piRNA profiling revealed unique circulating piRNA signatures of cholangiocarcinoma and gallbladder carcinoma[J]. Acta Biochim Biophys Sin(Shanghai), 2020, 52(5):475-484. |
[16] | GU X, WANG C, DENG H, et al. Exosomal piRNA profiling revealed unique circulating piRNA signatures of cholangiocarcinoma and gallbladder carcinoma[J]. Acta Biochim Biophys Sin(Shanghai), 2020, 52(5):475-484. |
[17] |
QU A, WANG W, YANG Y, et al. A serum piRNA signature as promising non-invasive diagnostic and prognostic biomarkers for colorectal cancer[J]. Cancer Manag Res, 2019, 11:3703-3720.
DOI URL |
[18] |
MAI D, DING P, TAN L, et al. PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma[J]. Theranostics, 2018, 8(19):5213-5230.
DOI URL |
[19] |
MAI D, ZHENG Y, GUO H, et al. Serum piRNA-54265 is a New Biomarker for early detection and clinical surveillance of human colorectal cancer[J]. Theranostics, 2020, 10(19):8468-8478.
DOI URL |
[20] | SABBAH N A, ABDALLA W M, MAWLA W A, et al. PiRNA-823 is a unique potential diagnostic non-invasive biomarker in colorectal cancer patients[J]. Genes(Basel), 2021, 12(4):598. |
[21] |
WANG Z, YANG H, MA D, et al. Serum PIWI-interacting RNAs piR-020619 and piR-020450 are promising novel biomarkers for early detection of colorectal cancer[J]. Cancer Epidemiol Biomarkers Prev, 2020, 29(5):990-998.
DOI URL |
[22] |
CORDEIRO A, NAVARRO A, GAYA A, et al. PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma[J]. Oncotarget, 2016, 7(29):46002-46013.
DOI URL |
[23] |
YAN H, WU Q L, SUN C Y, et al. piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma[J]. Leukemia, 2015, 29(1):196-206.
DOI URL |
[24] |
LI B, HONG J, HONG M, et al. piRNA-823 delivered by multiple myeloma-derived extracellular vesicles promoted tumorigenesis through re-educating endothelial cells in the tumor environment[J]. Oncogene, 2019, 38(26):5227-5238.
DOI URL |
[25] |
MA H, WANG H, TIAN F, et al. PIWI-interacting RNA-004800 is regulated by S1P receptor signaling pathway to keep myeloma cell survival[J]. Front Oncol, 2020, 10:438.
DOI URL |
[26] | YANG J, XUE F T, LI Y Y, et al. Exosomal piRNA sequencing reveals differences between heart failure and healthy patients[J]. Eur Rev Med Pharmacol Sci, 2018, 22(22):7952-7961. |
[27] | SUNDAR I K, LI D, RAHMAN I. Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers[J]. J Extracell Vesicles, 2019, 8(1):1684816. |
[28] | JIA S, ZHANG Q, WANG Y, et al. PIWI-interacting RNA sequencing profiles in maternal plasma-derived exosomes reveal novel non-invasive prenatal biomarkers for the early diagnosis of nonsyndromic cleft lip and palate[J]. EBioMedicine, 2021, 65:103253. |
[29] | SABO A A, BIROLO G, NACCARATI A, et al. Small non-coding RNA profiling in plasma extracellular vesicles of bladder cancer patients by next-generation sequencing:expression levels of miR-126-3p and piR-5936 increase with higher histologic grades[J]. Cancers(Basel), 2020, 12(6):1507. |
[30] |
KUMAR K, TRZYBULSKA D, TSATSANIS C, et al. Identification of circulating small non-coding RNAs in relation to male subfertility and reproductive hormones[J]. Mol Cell Endocrinol, 2019, 492:110443.
DOI URL |
[31] |
VOJTECH L, WOO S, HUGHES S, et al. Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions[J]. Nucleic Acids Res, 2014, 42(11):7290-7304.
DOI URL |
[32] |
CHEN H, XIE Y, LI Y, et al. Outcome prediction of microdissection testicular sperm extraction based on extracellular vesicles piRNAs[J]. J Assist Reprod Genet, 2021, 38(6):1429-1439.
DOI URL |
[33] |
NAGIRNAJA L, MØRUP N, NIELSEN J E, et al. Variant PNLDC1,defective piRNA processing,and azoospermia[J]. N Engl J Med, 2021, 385(8):707-719.
DOI URL |
[34] |
ILIEV R, FEDORKO M, MACHACKOVA T, et al. Expression levels of PIWIinteracting RNA,piR-823,are deregulated in tumor tissue,blood serum and urine of patients with renal cell carcinoma[J]. Anticancer Research, 2016, 36(12):6419-6424.
DOI URL |
[35] | MARKERT L, HOLDMANN J, KLINGER C, et al. Small RNAs as biomarkers to differentiate benign and malign prostate diseases:an alternative for transrectal punch biopsy of the prostate?[J]. PLoS One, 2021, 16(3):e0247930. |
[36] |
HE L, PING F, FAN Z, et al. Salivary exosomal miR-24-3p serves as a potential detective biomarker for oral squamous cell carcinoma screening[J]. Biomed Pharmacother, 2020, 121:109553.
DOI URL |
[37] |
ZHAO S Y, WANG J, OUYANG S B, et al. Salivary circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as novel biomarkers for the diagnosis of oral squamous cell carcinoma[J]. Cell Physiol Biochem, 2018, 47(6):2511-2521.
DOI URL |
[38] |
LI K, LIN Y, LUO Y, et al. A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma:a multicenter prospective study[J]. Mol Cancer, 2022, 21(1):21.
DOI URL |
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