Semaphorin 3A detection in the diagnosis of kidney injury

doi:10.3969/j.issn.1673-8640.2017.011.029

Abstract

Abstract:

Semaphorin family is a series of proteins which control blood vessels and organs,cell migration,cell factor and axon growth. Among this family,semaphorin 3A（Sema 3A） is a member being studied thoroughly. Recently,several studies show Sema 3A is a new biomarker for the early diagnosis of acute kidney injury. It has been confirmed as a new marker both for acute kidney injury and chronic kidney diseases,and a large amount of data are needed to support its diagnostic performance. Furthermore,Sema 3A is a new and hot research object as a promising target for future clinical treatment in kidney injury. This review focuses on Sema 3A-a new kidney injury diagnosis biomarker.

Key words: Semaphorin 3A, Acute kidney injury, Biomarker

CLC Number:

R446.1

ZHANG Yixin, WEI Dianjun, NING Li. Semaphorin 3A detection in the diagnosis of kidney injury[J]. Laboratory Medicine, 2017, 32(11): 1070-1074.

References 37

[1]	KOLODKIN A L,MATTHES D J,O'CONNOR T P,et al. Fasciclin Ⅳ:sequence,expression,and function during growth cone guidance in the grasshopper embryo[J]. Neuron,1992,9(5):831-845.
[2]	EPSTEIN J A,AGHAJANIAN H,SINGH M K.Semaphorin signaling in cardiovascular development[J]. Cell Metab,2015,21(2):163-173.
[3]	LUO Y,RAIBLE D,RAPER J A.Collapsin:a protein in brain that induces the collapse and paralysis of neuronal growth cones[J]. Cell,1993,75(2):217-227.
[4]	NEUFELD G,SABAG A D,RABINOVICZ N,et al.Semaphorins in angiogenesis and tumor progression[J]. Cold Spring Harb Perspect Med,2012,2(1):a006718.
[5]	TAKAMATSU H,KUMANOGOH A.Diverse roles for semaphorin-plexin signaling in the immune system[J]. Trends Immunol,2012,33(3):127-135.
[6]	CORA D,ASTANINA E,GIRAUDO E,et al.Semaphorins in cardiovascular medicine[J]. Trends Mol Med,2014,20(10):589-598.
[7]	JONGBLOETS B C,PASTERKAMP R J.Semaphorin signalling during development[J]. Development,2014,141(17):3292-3297.
[8]	VILLEGAS G,TUFRO A.Ontogeny of semaphorins 3A and 3F and their receptors neuropilins 1 and 2 in the kidney[J]. Mech Dev,2002,119(Suppl 1):S149-S153.
[9]	REIDY K J,VILLEGAS G,TEICHMAN J,et al.Semaphorin3a regulates endothelial cell number and podocyte differentiation during glomerular development[J]. Development,2009,136(23):3979-3989.
[10]	REIDY K,TUFRO A.Semaphorins in kidney development and disease:modulators of ureteric bud branching,vascular morphogenesis,and podocyte-endothelial crosstalk[J]. Pediatr Nephrol,2011,26(9):1407-1412.
[11]	TRAN T S,KOLODKIN A L,BHARADWAJ R.Semaphorin regulation of cellular morphology[J]. Annu Rev Cell Dev Biol,2007,23:263-292.
[12]	Semaphorin Nomenclature Committee.Unified nomenclature for the semaphorins/collapsins[J]. Cell,1999,97(5):551-552.
[13]	FEINER L,KOPPEL A M,KOBAYASHI H,et al.Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ[J]. Neuron,1997,19(3):539-545.
[14]	LIU H,JUO Z S,SHIM A H,et al.Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1[J]. Cell,2010,142(5):749-761.
[15]	JANSSEN B J,ROBINSON R A,PÉREZ-BRANGULI F,et al. Structural basis of semaphorin-plexin signalling[J]. Nature,2010,467(7319):1118-1122.
[16]	NOGI T,YASUI N,MIHARA E,et al.Structural basis for semaphorin signalling through the plexin receptor[J]. Nature,2010,467(7319):1123-1127.
[17]	NEGISHI M,OINUMA I,KATOH H.R-ras as a key player for signaling pathway of plexins[J]. Mol Neurobiol,2005,32(3):217-222.
[18]	GU C,RODRIGUEZ E R,REIMERT D V,et al.Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development[J]. Dev Cell,2003,5(1):45-57.
[19]	HILLMAN R T,FENG B Y,NI J,et al.Neuropilins are positive regulators of Hedgehog signal transduction[J]. Genes Dev,2011,25(22):2333-2346.
[20]	MUDERS M H.Neuropilin and neuropilin associated molecules as new molecular targets in pancreatic adenocarcinoma[J]. Anticancer Agents Med Chem,2011,11(5):442-447.
[21]	RIZZOLIO S,TAMAGNONE L.Multifaceted role of neuropilins in cancer[J]. Curr Med Chem,2011,18(23):3563-3575.
[22]	OHTA K,MIZUTANI A,KAWAKAMI A,et al.Plexin:a novel neuronal cell surface molecule that mediates cell adhesion via a homophilic binding mechanism in the presence of calcium ions[J]. Neuron,1995,14(6):1189-1199.
[23]	BORK P,DOERKS T,SPRINGER T A,et al.Domains in plexins:links to integrins and transcription factors[J]. Trends Biochem Sci,1999,24(7):261-263.
[24]	KLOSTERMANN A,LOHRUM M,ADAMS R H,et al.The chemorepulsive activity of the axonal guidance signal semaphorin D requires dimerization[J]. J Biol Chem,1998,273(13):7326-7331.
[25]	CHEN H,CHÉDOTAL A,HE Z,et al. Neuropilin-2,a novel member of the neuropilin family,is a high affinity receptor for the semaphorins Sema E and Sema Ⅳ but not Sema Ⅲ[J]. Neuron,1997,19(3):547-559.
[26]	KOLODKIN A L,LEVENGOOD D V,ROWE E G,et al.Neuropilin is a semaphorin Ⅲ receptor[J]. Cell,1997,90(4):753-762.
[27]	HE Z,TESSIER-LAVIGNE M.Neuropilin is a receptor for the axonal chemorepellent Semaphorin Ⅲ[J]. Cell,1997,90(4):739-751.
[28]	GOSHIMA Y,NAKAMURA F,STRITTMATTER P,et al.Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33[J]. Nature,1995,376(6540):509-514.
[29]	JAYAKUMAR C,RANGANATHAN P,DEVARAJAN P,et al.Semaphorin 3A is a new early diagnostic biomarker of experimental and pediatric acute kidney injury[J]. PLoS One,2013,8(3):e58446.
[30]	VIAZZI F,RAMESH G,JAYAKUMAR C,et al.Increased urine semaphorin-3A is associated with renal damage in hypertensive patients with chronic kidney disease:a nested case-control study[J]. J Nephrol,2015,28(3):315-320.
[31]	TUFRO A.Semaphorin3a signaling,podocyte shape,and glomerular disease[J]. Pediatr Nephrol,2014,29(4):751-755.
[32]	REIDY K J,AGGARWAL P K,JIMENEZ J J,et al.Excess podocyte semaphorin-3A leads to glomerular disease involving plexinA1-nephrin interaction[J]. Am J Pathol,2013,183(4):1156-1168.
[33]	RANGANATHAN P,JAYAKUMAR C,MOHAMED R,et al.Semaphorin 3A inactivation suppresses ischemia-reperfusion-induced inflammation and acute kidney injury[J]. Am J Physiol Renal Physiol,2014,307(2):F183-F194.
[34]	MOHAMED R,RANGANATHAN P,JAYAKUMAR C,et al.Urinary semaphorin 3A correlates with diabetic proteinuria and mediates diabetic nephropathy and associated inflammation in mice[J]. J Mol Med(Berl),2014,92(12):1245-1256.
[35]	DOI K,NOIRI E,NANGAKU M,et al.Repulsive guidance cue semaphorin 3A in urine predicts the progression of acute kidney injury in adult patients from a mixed intensive care unit[J]. Nephrol Dial Transplant,2014,29(1):73-80.
[36]	田漫漫,赵双平. 尿Sema3A对重症监护病房患者急性肾损伤的早期诊断价值[J]. 中华医学杂志,2015,95(19):1457-1462.
[37]	LEWANDOWSKA L,MATUSZKIEWICZ-ROWINSKA J,JAYAKUMAR C,et al.Netrin-1 and semaphorin 3A predict the development of acute kidney injury in liver transplant patients[J]. PLoS One,2014,9(10):e107898.