Abstract: Objective　To investigate the clinical significance on the combined detection of B-type natriuretic peptide（BNP），high sensitive C reactive protein（hs-CRP），cardiac troponin I（cTnI）and uric acid（UA） in the diagnosis of heart failure（HF）. Methods　The serum levels of BNP，hs-CRP，cTnI and UA in 292 patients with different etiological factors and grades of HF[according to the cardiac function standard of New York Heart Association （NYHA）Ⅰ-Ⅳ] and 100 healthy controls were determined. The sensitivity and specificity of 4 parameters were evaluated by receiver operating characteristic （ROC） curve.  Results　The levels of BNP，hs-CRP，cTnI and UA in different grades of HF had statistical significance （P＜0.05）. In addition，the grade was worse，and its concentration was higher. The levels of BNP and hs-CRP showed statistical significance between HF NYHAⅠ grade patients and healthy controls （P＜0.05）, and the levels of cTnI and UA had no statistical significance between the healthy controls and HF NYHAⅠ grade patients（P＞0.05）. The sensitivity of combined detection was 90.1% in early HF diagnosis, which was higher significantly than that of the individual detection （P＜0.01）.  Conclusions　The significant clinical significance on the combined detection of the serum BNP，hs-CRP，cTnI and UA provides reference support in the diagnosis of early HF.

Key words: B-type natriuretic peptide, High sensitive C reactive protein, Cardiac troponin I, Uric acid, Heart failure