Abstract:

Objective To evaluate the value of random urine uric acid/creatinine （UA/Cr） in the classification of hyperuricemia （HUA） patients in Karamay. Methods Totally，126 patients with HUA and 124 healthy subjects in Karamay Hospital of Integrated Traditional Chinese and Western Medicine （People's Hospital） from April 2022 to May 2023 were enrolled. The total cholesterol （TC），triglyceride （TG），high-density lipoprotein cholesterol （HDL-C），fasting blood glucose （FBG），serum urea （SU），serum uric acid （SUA），serum creatinine （SCr），urinary uric acid （UUA） and urinary creatinine （UCr） were determined. The correlation between random urine UA/Cr and 24 h urine uric acid excretion （UUE） and fractional excretion of uric acid（FEUA） in HUA group was analyzed by Spearman analysis. Receiver operating characteristic （ROC） curve was used to evaluate the efficiency of random urine UA/Cr in HUA group. Results There was no statistical significance in gender，age，TC，HDL-C，SU and estimated glomerular filtration rate（eGFR） between HUA group and control group （P>0.05）. Body mass index，TG，FBG，SUA and SCr in HUA group were higher than those in control group （P<0.05），while urinary pH value in HUA group was lower than that in control group （P<0.05）. There was statistical significance for UUA，UUE，FEUA and random urine UA/Cr between renal excretion poor type and renal overload type（P<0.05）. The UUA，UUE and random urine UA/Cr of renal excretion poor type were lower than those of mixed type （P<0.05）. In HUA group，random urine UA/Cr was positively correlated with UUE and FEUA（r were 0.778 4 and 0.708 6，P<0.05），respectively. The ROC curve for random urine UA/Cr predictive typing in HUA group was drawn with FEUA 5.5% as the cut-off point. The cut-off value of random urine UA/Cr predictive typing was 0.297，the sensitivity was 92.5%，the specificity was 64.4%，and the area under curve（AUC） was 0.804. With UUE≤600 mg·d-1·（1.73 m2）-1 as the cut-off point，the ROC curve for random urine UA/Cr predictive typing was drawn in HUA group. The cut-off value of random urine UA/Cr predictive typing was 0.302，the sensitivity was 87.6%，the specificity was 100.0%，and the AUC was 0.979. For renal excretion poor type，random urine UA/Cr typing cut-off value was <0.297；for renal overload type，the cut-off value of random urine UA/Cr typing was >0.302；for other types，the cut-off value of random urine UA/Cr typing was ≥0.297 and ≤0.302；mixed type could not be screened according to statistical results. Conclusions Random urine UA/Cr can provide reference for the classification of HUA in Karamay.

Key words: Random urine uric acid/creatinine, Hyperuricemia, Uric acid excretion, Fractional excretion of uric acid