Analysis of the pathogens isolated from blood specimens of neonates and their antibiotic resistance

Abstract

Abstract: Objective　To investigate the distribution and antibiotic resistance of pathogens isolated from blood specimens of neonates. Methods　Biphasic blood culture bottle was used to culture the blood of the neonates. Isolated strains were identified，and their drug sensitivity tests were completed by VITEK 32 system．Results　The results showed that Gram-positive cocci accounted for 70.6%，in which Staphylococcus epidermidis accounted mainly，and Gram-negative bacteria accounted for 28.4%． Gram-positive cocci were sensitive to vancomycin，and Gram-negative bacteria were sensitive to carbapenem. Conclusions　The antibiotic resistance determination of pathogens isolated form blood specimens of neonates should be paid attention. Choosing rational antibiotics can reduce the antibiotic resistance and improve the clinical curative effect.

null

Key words: Pathogen, Blood culture, Antibiotic resistance, Neonate

SONG Haiying;CHENG Xiaojing;ZHANG Wenrong. Analysis of the pathogens isolated from blood specimens of neonates and their antibiotic resistance[J]. , 2012, 27(7): 540-543.

References

[1]金汉珍，黄德珉，官希吉，等．实用新生儿学[M]．第3版.北京：人民卫生出版社，2003：342-349.
[2]杨敬芳，李继红，王　鑫，等．6 445份血培养分离菌的分布特征及耐药谱型研究[J]．中华医院感染学杂志，2003，13（6）：575-577．
[3]高文静，曾淑敏，莫顺华.新生儿血培养病原菌分布及耐药性分析[J].浙江临床医学，2010，12（8）：884-885.
[4]张世勇，胡佳林，许　涛．636例血标本的病原菌种类分布与耐药性研究[J]．检验医学与临床，2007，4（3）：173-175.
[5]Vergnano S，Sharland M，Kazembe P，et al. Neonatal sepsis：an international perspective[J]．Arch Dis Child Fetal Neonatal Ed，2005，90（3）：F220-F224．
[6]欧阳颖，梁立阳，苏浩彬，等．新生儿败血症病原学分析[J]．中国新生儿科杂志，2007，22（5）：302-303.
[7]Urrea M，Iriondo M，Thio M，et al. A prospective incidence study of nosocomial infections in a neonatal care unit[J]. Am J Infect Control，2003，31（8）：505-507．
[8]陈　敏，周陶友，陈文昭，等．耐甲氧西林金黄色葡萄球菌感染的临床和耐药性[J]．中华医院感染学杂志，2004，14（2）：223-225．
[9]余加林，贾慧群，毋灿荣，等．新生儿感染耐甲氧西林葡萄球菌的药敏分析[J]．儿科药学杂志，2001，7（1）：20-22.
[10]蔡　琰，范昕建，吕晓菊，等．产超广谱β-内酰胺酶肠杆菌科细菌耐药性及基因型检测[J]．中国抗生素杂志，2003，28（2）：82-86.
[11]吴仕孝．喹喏酮类药物在儿科应用的新认识[J]．中华儿科杂志，1999，37（12）：773-774．
[12]Korman TM，Turnidge JD，Grayson ML. Risk factors for adverse cutaneous reactions associated with intra-venous vancomycin[J]．J Antimicrob Chemother，1997，39（3）：371-381.
[13]Volante E，Moretti S，Pisani F，et al．Early diagnosis of bacterial infection in the neonate[J]．J Matern Fetal Neonatal Med，2004，16（Suppl 2）：13-16．
[14]Tiskumara R，Fakharee SH，Liu CQ，et al．Neonatal infections in Asia[J]．Arch Dis Child Fetal Neonatal Ed，2009，94（2）：F144-F148．
[15]郭玉芬，甄景慧，张美和．北京儿童医院血培养检出菌17年的变迁及耐药性探讨[J]．中华儿科杂志，2000，16（12）：750-754.