Abstract:

Objective To investigate the correlation between serum hypoxia inducible factor-1 alpha（HIF-1α） and creatine kinase isoenzyme-BB（CK-BB）and the severity of neonatal hypoxic ischemic encephalopathy（HIE）. Methods A total of 230 neonates with HIE were enrolled and classified into 102 cases of mild,71 cases of moderate and 57 cases of severe according to the disease severity. Totally,200 healthy neonates were enrolled as healthy control group. Serum levels of HIF-1α and CK-BB were determined,and the 20 items of neonatal behavioral neurological assessment（NBNA） score were used to evaluate the severity of brain injury. Pearson correlation analysis was used to evaluate the correlation between serum HIF-1α,CK-BB levels and NBNA score. Results The levels of serum HIF-1α and CK-BB in neonatal HIE group were higher than those in healthy control group（P<0.001）,and the NBNA score was lower than that in healthy control group（P<0.001）. Serum HIF-1α and CK-BB levels were negatively correlated with NBNA scores（r=-0.701 and -0.683,P<0.05）. In neonatal HIE group,with the increase of disease severity,the levels of serum HIF-1α and CK-BB were increased in turn（P<0.001）,and the NBNA scores were decreased in turn（P<0.001）. Conclusions Serum HIF-1α and CK-BB may be used as the indicators for evaluating the disease severity in HIE neonates.

Key words: Hypoxia inducible factor-1 alpha, Creatine kinase isoenzyme-BB, Hypoxic ischemic encephalopathy, Neonate