Abstract:

Objective　To investigate the clinical significance of erythrocyte glucose-6-phosphate dehydrogenase（G6PD）activity detection in pathological jaundice of neonate. MethodsA total of 200 cases of neonatal pathological jaundice（jaundice group）and 100 healthy newborns（control group） were enrolled and detected for G6PD activity， and the Resultswere compared. On the basis of G6PD deficiency judgment standard（＜2.5 U/L）， 200 cases of neonatal pathological jaundice were classified into G6PD deficiency group and non G6PD deficiency group. The comparison of bilirubin concentration and G6PD activity between the 2 groups was performed. ResultsThe concentration of bilirubin in jaundice group was significantly higher than that in control group（P＜0.05）， but the G6PD activity in jaundice group was significantly lower than that in control group（P＜0.05）. In G6PD deficiency group， bilirubin concentration was higher than that in non G6PD deficiency group（P＜0.05）. ConclusionsG6PD deficiency is an important cause of neonatal pathological jaundice. Strengthening the monitoring of neonatal G6PD can provide the reference for clinical prevention and treatment of neonatal pathological jaundice.

Key words: Glucose-6-phosphate dehydrogenase, Pathological jaundice, Neonate