Abstract: Objective　To investigate primarily the differences of serum high-sensitivity cardiac troponin-T （hs-cTnT） in healthy children in different periods and the changes of hs-cTnT in neonates with pathological jaundice，and compare it with creatine kinase MB （CK-MB） and serum total bilirubin （TBil）. Methods　The reference range of serum hs-cTnT in children was determined from 225 healthy children in age from 1 d to 6 years. The levels of hs-cTnT，CK-MB，TBil and direct bilirubin (DBil) were determined and compared between 46 neonates with pathological jaundice and 30 control neonates. The hs-cTnT levels were also compared with those of 31 neonates with preterm delivery，43 neonates with hypoxia and 12 neonates with infections. Results　The reference interval of hs-cTnT was 0-0.074 μg/L. The level of serum hs-cTnT in healthy children decreased with the increasing of age and reached the adult′s level at 6 months after birth. The average level of hs-cTnT in 46 neonates with pathological jaundice was（0.120±0.095）μg/L，and was significantly higher than those in the control group[（0.035±0.020）μg/L]，preterm delivery group [（0.065±0.035） μg/L]，infection group [（0.037±0.017） μg/L] and hypoxia group [（0.051±0.026） μg/L]（P＜0.001）. The levels of TBil, DBil and CK-MB in neonates with pathological jaundice were also significantly higher than those in the control group (P＜0.000 1 and P＜0.05). There was no significant correlation between hs-cTnT and TBil in neonates with pathological jaundice （r=0.088 6，P＞0.05）. Conclusions　In healthy children，the level of serum hs-cTnT decreases with the increasing of age and reaches the adult′s level at 6 months after birth. The level of serum hs-cTnT can be used to indicate the myocardial injury in neonates with pathological jaundice and provide the reference for the early diagnosis，laboratory examination and following therapy in neonates with pathological jaundice.

Key words: High-sensitivity cardiac troponin-T, Neonate, Pathological jaundice