Abstract: Objective　To analyze the diagnostic performances of laboratory kidney function tests for chronic kidney disease.  Methods　A total of 73 patients with chronic kidney disease were classified into 3 groups according to different estimated glomerular filtration rate (eGFR)：Group A（33 cases），eGFR:＞60 mL/（min·1.73 m²）；Group B（32 cases），eGFR: 30-60 mL/（min·1.73 m²）；Group C（8 cases），eGFR:＜30 mL/（min·1.73 m²）. The patients with chronic kidney disease，40 patients with high risk of chronic kidney disease （with diabetes mellitus or hypertension） and 32 healthy subjects were compared with the testing of random urine microalbumin （U-mALb）/creatinine (Cr) ratio, random urine protein (UP)/Cr ratio, 24h-urine microalbumin（24h-UmALb），24h-urine protein（24hUP），serum urea，Cr，uric acid（UA） and cystatin C（CysC）. With the gold standard methods ［the cut-off value of 24h UP or eGFR was >150 mg or ＜60 mL/（min·1.73 m²），respectively］， the diagnostic sensitivity, specificity, negative predictive value, positive predictive value, negative and positive likelihood ratios and accuracy were calculated. Results　There were significant differences in the results of all tests（U-mALb/Cr, UP/Cr, 24hU-mALb, urea, UA and CysC） between the 3 groups of chronic kidney disease（P<0.05）. There were also significant differences in the results of all the tests except UA between the Group A of chronic kidney disease and the group with high risk of chronic kidney disease（P<0.05）. There only existed significant difference in the results of UA and CysC between the group of healthy subjects and the group with high risk of chronic kidney disease（P<0.05）. The diagnostic performances of U-mAlb/Cr, UP/Cr, 24 h U-mAlb, urea, UA and Cys C were as follows：negative likelihood ratios were 0.17，0.22，0.14，0.67，0.66 and 0.51；positive likelihood ratios were 7.73，78，28.7，34，3.73 and 5.00；accuracies were 0.87，0.88，0.92，0.66，0.65 and 0.74. Conclusions　The 24hU-mALb has the best accuracy in the diagnosis of chronic kidney disease. UP/Cr and U-mALb/Cr may be used as screening tests for the diagnosis of chronic kidney disease，because their accuracies of diagnostic performance for chronic kidney disease are closest to that of 24 h U-mALb, and eGFR may be mainly used in the classification of chronic kidney disease.

Key words: Microalbumin, Urine protein, Creatinine, 24h-urine, Random urine, Diagnostic performance