Abstract:

Objective To investigate the combined determination of serum amyloid A protein（SAA）,cystatin C（Cys C） and urinary albumin-to-creatinine ratio（ACR） in the diagnosis of early diabetic nephropathy（DN）. Methods A total of 100 patients with type 2 diabetes mellitus（T2DM） and 100 patients with early DN were enrolled,and 50 healthy subjects were enrolled as healthy control group. The levels of serum SAA and Cys C and urinary ACR were determined. Pearson correlation analysis was performed,and receiver operating characteristic（ROC） curve was used. Results Serum SAA and Cys C levels and urinary ACR increased in turn in healthy control,T2DM and DN groups（P<0.05）. Serum SAA and Cys C levels and urinary ACR in DN group were positively correlated（r=0.631 and 0.662,P<0.05）. The area under ROC curve of the combined determination of serum SAA,Cys C and urinary ACR was bigger than those of the combined determinations of 2 items and single determinations. Conclusions The combined determination of serum SAA,Cys C and urinary ACR has higher accuracy than those of single determinations in the diagnosis of early DN.

Key words: Amyloid A protein, Cystatin C, Albumin-to-creatinine ratio, Diabetic nephropathy