Abstract:

Objective To assess the status of renal function of cases with drug addicts by determining urinary total protein（TP）,microalbumin（mAlb） and alpha 1-microglobulin（α₁-MG） levels. Methods Urinary TP,mAlb and α₁-MG levels were determined in 307 cases with drug addicts and 201 healthy subjects （healthy control group）. According to the types of drugs taken by the cases with drug addicts,they were classified into methamphetamine group（213 cases）,morphine group（30 cases）,mixed group（36 cases） and the other group（28 cases）. Their results were compared. Results The TP,mAlb and α₁-MG levels in drug addict group were higher than those in healthy control group （P<0.000 1）. The mAlb level in methamphetamine group was higher than that in morphine group （P<0.05）,but the TP and α₁-MG levels were lower （P<0.05）. The mAlb level in morphine group was lower than that in mixed group （P<0.05）. The α₁-MG level in mixed group was higher than that in the other group （P<0.05）. The urinary TP and α₁-MG levels of male drug addicts were higher than those of female drug addicts（P<0.05,P<0.001）,and mAlb had no statistical significance （P>0.05）. Conclusions Methamphetamine tends to cause serious damage to glomerulus,while morphine tends to cause serious damage to renal tubule . It should pay attention to strength the health intervention for drug addicts and control the harm of drugs.

Key words: Total protein, Microalbumin, Alpha 1-microglobulin, Renal function, Drug addicts