Application of enhanced cardiac troponin I determination in clinical diagnosis of acute coronary syndrome

Abstract

Abstract: Objective　To observe the distribution of enhanced cardiac troponin I (cTnI)［high sensitive cTnI (hs-cTnI)］ in healthy subjects and patients with acute coronary syndrome (ACS), and investigate the application of hs-cTnI in the diagnosis of ACS. Methods　A total of 80 ACS patients who had chest pain onset within 12 h, 26 stable angina (SA) patients and 60 healthy controls were enrolled. The hs-cTnI，conventional cTnI，blood routine tests, C reactive protein (CRP) and other indices were determined among the groups. The receiver operating characteristic (ROC) curve was used to analyze the diagnosis performance of hs-cTnI determination. Results　The concentrations of hs-cTnI had statistical significance among ACS, SA and control groups. The area under ROC curve (AUC) of hs-cTnI (0.986±0.014) was significantly higher than that of conventional cTnI (0.915±0.035, P=0.034). The AUC of hs-cTnI had no difference with those of hs-cTnI combined with CRP, neutropil granulocyte percentage/lymphocyte percentage ratio and white blood cell count (0.978±0.018,P>0.05). When the cut-off value was 0.02 ng/mL,the diagnosis performance was the best. Conclusions　Compared with the conventional cTnI, the hs-cTnI has diagnosis performance in early diagnosis of ACS. There is no diagnosis value in combined of inflammation indices.Objective　To observe the distribution of enhanced cardiac troponin I (cTnI)［high sensitive cTnI (hs-cTnI)］ in healthy subjects and patients with acute coronary syndrome (ACS), and investigate the application of hs-cTnI in the diagnosis of ACS. Methods　A total of 80 ACS patients who had chest pain onset within 12 h, 26 stable angina (SA) patients and 60 healthy controls were enrolled. The hs-cTnI，conventional cTnI，blood routine tests, C reactive protein (CRP) and other indices were determined among the groups. The receiver operating characteristic (ROC) curve was used to analyze the diagnosis performance of hs-cTnI determination. Results　The concentrations of hs-cTnI had statistical significance among ACS, SA and control groups. The area under ROC curve (AUC) of hs-cTnI (0.986±0.014) was significantly higher than that of conventional cTnI (0.915±0.035, P=0.034). The AUC of hs-cTnI had no difference with those of hs-cTnI combined with CRP, neutropil granulocyte percentage/lymphocyte percentage ratio and white blood cell count (0.978±0.018,P>0.05). When the cut-off value was 0.02 ng/mL,the diagnosis performance was the best. Conclusions　Compared with the conventional cTnI, the hs-cTnI has diagnosis performance in early diagnosis of ACS. There is no diagnosis value in combined of inflammation indices.

Key words: Enhanced cardiac troponin I, Acute coronary syndrome, Receiver operating characteristic curve

ZHANG Guang-Hui;DENG Lin;FEI Ai-Hua;DAI Li-Hua;LU Yi-Wen;SHEN Li-Song. Application of enhanced cardiac troponin I determination in clinical diagnosis of acute coronary syndrome[J]. , 2012, 27(5): 345-348.

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