Abstract:

Objective To investigate the role of serum soluble triggering receptor expressed on myeloid cell-1（sTREM-1） in the diagnosis of sepsis. Methods A total of 50 patients with sepsis were enrolled as sepsis group,and 50 patients with non-sepsis were enrolled as control group. Serum samples were collected at the 1st day of admission. The level of sTREM-1 was determined by quantitative enzyme-linked immunosorbent assay（ELISA）. The level of procalcitonin（PCT） was determined by electro-chemiluminescence. The level of C-reactive protein（CRP） was determined by immunoturbidimetry. Meanwhile,anti-coagulated blood was collected for determining white blood cell（WBC） count．The efficiency of sTREM-1,PCT,CRP and WBC count for the diagnosis of sepsis was evaluated by receiver operating characteristic（ROC） curve. Results The levels of sTREM-1 and PCT in sepsis group were higher than those in control group（P<0.01）. The areas under ROC curves（AUC） of sTREM-1,PCT,CRP and WBC count in the diagnosis of sepsis were 0.922,0.775,0.728 and 0.685,respectively. The optimal point of sTREM-1 for the diagnosis of sepsis was 212.25 ng/L,and the sensitivity and specificity were 0.84 and 0.90,respectively. The optimal point of PCT was 0.475 ng/mL,and the sensitivity and specificity were 0.78 and 0.68,respectively. Conclusions Serum sTREM-1 with high diagnosis efficiency can be used as an early indicator for the diagnosis of sepsis.

Key words: Soluble triggering receptor expressed on myeloid cell-1, Procalcitonin, Receiver operating characteristic curve, Sepsis