Research progress on neutrophil-to-lymphocyte ratio in the diagnosis and treatment of coronary heart disease

doi:10.3969/j.issn.1673-8640.2026.03.014

Abstract

Abstract:

Coronary heart disease（CHD）as a common cardiovascular disease，had an increasing incidence and mortality rate year by year，and the age of onset tends to be younger，posing a serious threat to human life safety. It is of significance to find inexpensive，fast and simple diagnostic tools to alleviate the enormous pressure that CHD brings to society. Inflammatory biomarker neutrophil-to-lymphocyte ratio（NLR）had been a novel non-invasive biomarker for assessing the degree of myocardial ischemia in CHD patients，it plays a role in the diagnosis，severity assessment and prognosis judgement of CHD. This review focuses on the epidemiology of CHD，the relationship between inflammation and CHD and the current research status of inflammatory biomarker NLR in the field of CHD，providing a reference for further understanding the potential of NLR in the diagnosis and treatment of CHD.

Key words: Neutrophil-to-lymphocyte ratio, Coronary heart disease, Inflammatory response

CLC Number:

R446.1

XU Hongqiang, PENG Haibo, XU Huan, LUO Zhonglan, XIONG Guanghai, LI Zhen, LUO Jie. Research progress on neutrophil-to-lymphocyte ratio in the diagnosis and treatment of coronary heart disease[J]. Laboratory Medicine, 2026, 41(3): 291-298.

Figures/Tables 1

References 49

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临床价值	作用	参考文献
诊断价值
升高	NLR≥2.36可作为CHD的独立危险因素	[27]
升高	NLR升高1个单位，CHD发病率增加1.6倍，诊断CHD的AUC为0.814	[26]
升高	结合CK-MB、hs-CRP、IMA诊断CHD的AUC为0.980	[28]
升高	结合中医辨证和Fib诊断CHD的AUC为0.776	[29]
病情严重程度评估价值
升高	预示着CHD患者斑块发生率高、稳定性差	[31]
升高	与CHD患者血管病变支数正相关	[32]
升高	与CHD患者Gensini积分正相关	[33]
预后价值
升高	预示着CHD患者的MACE发生率高	[43]
升高	以6.66作为截断值，对CHD患者住院期间不良事件预测的AUC为0.690	[38]
升高	预示着CHD患者总体死亡率、院内和远期死亡率增高	[39]

临床价值	作用	参考文献
诊断价值
升高	NLR≥2.36可作为CHD的独立危险因素	[27]
升高	NLR升高1个单位，CHD发病率增加1.6倍，诊断CHD的AUC为0.814	[26]
升高	结合CK-MB、hs-CRP、IMA诊断CHD的AUC为0.980	[28]
升高	结合中医辨证和Fib诊断CHD的AUC为0.776	[29]
病情严重程度评估价值
升高	预示着CHD患者斑块发生率高、稳定性差	[31]
升高	与CHD患者血管病变支数正相关	[32]
升高	与CHD患者Gensini积分正相关	[33]
预后价值
升高	预示着CHD患者的MACE发生率高	[43]
升高	以6.66作为截断值，对CHD患者住院期间不良事件预测的AUC为0.690	[38]
升高	预示着CHD患者总体死亡率、院内和远期死亡率增高	[39]