Laboratory Medicine ›› 2025, Vol. 40 ›› Issue (8): 824-828.DOI: 10.3969/j.issn.1673-8640.2025.08.018
Received:2024-12-16
Revised:2025-05-12
Online:2025-08-30
Published:2025-08-28
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URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2025.08.018
| 抗菌药物 | MIC①折点/ （ug·mL-1） | MIC值/ （ug·mL-1） | 判定结果 |
|---|---|---|---|
| 红霉素 | ≥8 | ≤0.5 | 敏感 |
| 阿奇霉素 | ≥0.5 | ≤0.5 | 敏感 |
| 萘啶酸 | ≥32 | 4 | 敏感 |
| 环丙沙星 | ≥1 | ≤0.5 | 敏感 |
| 庆大霉素 | ≥4 | ≤0.5 | 敏感 |
| 链霉素 | ≥32 | 1 | 敏感 |
| 氯霉素 | ≥32 | 1 | 敏感 |
| 氟苯尼考 | ≥8 | ≤0.5 | 敏感 |
| 四环素 | ≥2 | 16② | 耐药 |
| 泰利霉素 | ≥8 | ≤0.25 | 敏感 |
| 克林霉素 | ≥1 | ≤0.25 | 敏感 |
| 抗菌药物 | MIC①折点/ （ug·mL-1） | MIC值/ （ug·mL-1） | 判定结果 |
|---|---|---|---|
| 红霉素 | ≥8 | ≤0.5 | 敏感 |
| 阿奇霉素 | ≥0.5 | ≤0.5 | 敏感 |
| 萘啶酸 | ≥32 | 4 | 敏感 |
| 环丙沙星 | ≥1 | ≤0.5 | 敏感 |
| 庆大霉素 | ≥4 | ≤0.5 | 敏感 |
| 链霉素 | ≥32 | 1 | 敏感 |
| 氯霉素 | ≥32 | 1 | 敏感 |
| 氟苯尼考 | ≥8 | ≤0.5 | 敏感 |
| 四环素 | ≥2 | 16② | 耐药 |
| 泰利霉素 | ≥8 | ≤0.25 | 敏感 |
| 克林霉素 | ≥1 | ≤0.25 | 敏感 |
| 全基因组测序 | 表型/基因型 | 空肠弯曲菌 |
|---|---|---|
| PubMLST | MLST | 空肠弯曲菌ST51（ST443复合群） |
| ResFinder | 耐药基因 | tet（O）、blaOXA-193（OXA-61） |
| CARD | 耐药基因 | tet（O）、blaOXA-193（OXA-61）、cmeA、cmeB、cmeC、cmeR |
| VFDB | 鞭毛运动 | cheY、cheV、cheA、cheW、eptC、pseA、pseB、pseC、pseE/maf5、pseF、pseG、pseH、pseI、ptmA、ptmB、flaA、flaD、flaC、flaG、flgA、flgS、flgC、flgB、flgF、flgP、flgQ、flgH、flgG、flgE、flgD、flgR、flhA、flhB、flhF、flhG、fliA、fliD、fliE、fliF、fliG、fliH、fliK、fliL、fliM、fliN、fliP、fliY、fliR、fliS、fliW、motA、motB、flgI、flgJ、flgM、flgK、fliI、fliQ、pflA、rpoN60 |
| 非鞭毛运动 | Cj1416c、Cj1417c、Cj1419c、Cj1420c、cysC、kpsC、kpsS、kpsF、kpsD、kpsE、kpsT、kpsM1 | |
| Ⅳ型分泌系统 | ||
| 黏附因子 | cadF、pebA、jlpA3 | |
| 低脂糖 | mhA、htrB、gmhB、hldD、hldE、waaC、waaF、waaV8 | |
| 侵袭因子 | ciaB、ciaC | |
| 细胞致死膨胀毒素 | cdtA、cdtB、cdtC |
| 全基因组测序 | 表型/基因型 | 空肠弯曲菌 |
|---|---|---|
| PubMLST | MLST | 空肠弯曲菌ST51（ST443复合群） |
| ResFinder | 耐药基因 | tet（O）、blaOXA-193（OXA-61） |
| CARD | 耐药基因 | tet（O）、blaOXA-193（OXA-61）、cmeA、cmeB、cmeC、cmeR |
| VFDB | 鞭毛运动 | cheY、cheV、cheA、cheW、eptC、pseA、pseB、pseC、pseE/maf5、pseF、pseG、pseH、pseI、ptmA、ptmB、flaA、flaD、flaC、flaG、flgA、flgS、flgC、flgB、flgF、flgP、flgQ、flgH、flgG、flgE、flgD、flgR、flhA、flhB、flhF、flhG、fliA、fliD、fliE、fliF、fliG、fliH、fliK、fliL、fliM、fliN、fliP、fliY、fliR、fliS、fliW、motA、motB、flgI、flgJ、flgM、flgK、fliI、fliQ、pflA、rpoN60 |
| 非鞭毛运动 | Cj1416c、Cj1417c、Cj1419c、Cj1420c、cysC、kpsC、kpsS、kpsF、kpsD、kpsE、kpsT、kpsM1 | |
| Ⅳ型分泌系统 | ||
| 黏附因子 | cadF、pebA、jlpA3 | |
| 低脂糖 | mhA、htrB、gmhB、hldD、hldE、waaC、waaF、waaV8 | |
| 侵袭因子 | ciaB、ciaC | |
| 细胞致死膨胀毒素 | cdtA、cdtB、cdtC |
| [1] | BACHMANN N L, POLKINGHORNE A, TIMMS P. Chlamydia genomics:providing novel insights into chlamydial biology[J]. Trends Microbiol, 2014, 22(8):464-472. |
| [2] | ELWELL C, MIRRASHIDI K, ENGEL J. Chlamydia cell biology and pathogenesis[J]. Nat Rev Microbiol, 2016, 14(6):385-400. |
| [3] | COSTA D, IRAOLA G. Pathogenomics of emerging Campylobacter species[J]. Clin Microbiol Rev, 2019, 32(4):e00072. |
| [4] | COBO-DÍAZ J F, GONZÁLEZ DEL RÍO P, ÁLVAREZ-ORDÓÑEZ A. Whole resistome analysis in Campylobacter jejuni and C. coli genomes available in public repositories[J]. Front Microbiol, 2021,12:662144. |
| [5] | ELMI A, NASHER F, DORRELL N, et al. Revisiting Campylobacter jejuni virulence and fitness factors:role in sensing,adapting,and competing[J]. Front Cell Infect Microbiol, 2021,10:607704. |
| [6] | TINÉVEZ C, VELARDO F, RANC A G, et al. Retrospective multicentric study on Campylobacter spp. bacteremia in France:the campylobacteremia study[J]. Clin Infect Dis, 2022, 75(4):702-709. |
| [7] |
CHANG H, ZHANG L, GE Y, et al. A hospital-based case-control study of diarrhea in children in Shanghai[J]. Pediatr Infect Dis J, 2017, 36(11):1057-1063.
DOI PMID |
| [8] | 崔京涛, 闫文娟, 倪安平, 等. 五年间肺炎衣原体血清抗体检测及流行病学分析[J]. 中华医学杂志, 2014, 94(12):919-923. |
| [9] | 程福安. 肺炎衣原体IgM抗体检验在呼吸道感染患儿中的流行病学特征及其检测价值[J]. 中国医学创新, 2021, 18(12):93-96. |
| [10] | 中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会. 儿童社区获得性肺炎管理指南(试行)(上)[J]. 中华儿科杂志, 2007, 45(2):83-90. |
| [11] | O'HARA G A, FITCHETT J R A, KLEIN J L. Campylobacter bacteremia in London:a 44-year single-center study[J]. Diagn Microbiol Infect Dis, 2017, 89(1):67-71. |
| [12] | 许学斌. 司马慧兰[J]. 上海预防医学, 2021, 33(8):767. |
| [13] | 孙自捷, 段恕诚, 王顺林. 近年上海地区小儿急性腹泻中空肠弯曲菌检出情况的研究[J]. 中华儿科杂志, 1989, 27(6):339-340. |
| [14] | CHANG H, GUO J, WEI Z, et al. Aetiology of acute diarrhoea in children in Shanghai,2015-2018[J]. PLoS One, 2021, 16(4):e0249888. |
| [15] | OTSUKA Y, HAGIYA H, TAKAHASHI M, et al. Clinical characteristics of Campylobacter bacteremia:a multicenter retrospective study[J]. Sci Rep, 2023, 13(1):647. |
| [16] | FIEDORUK K, DANILUK T, ROZKIEWICZ D, et al. Whole-genome comparative analysis of Campylobacter jejuni strains isolated from patients with diarrhea in northeastern Poland[J]. Gut Pathog, 2019,11:32. |
| [17] | SHEPPARD S K, CHENG L, MÉRIC G, et al. Cryptic ecology among host generalist Campylobacter jejuni in domestic animals[J]. Mol Ecol, 2014, 23(10):2442-2451. |
| [18] | JORGENSEN F, ELLIS-IVERSEN J, RUSHTON S, et al. Influence of season and geography on Campylobacter jejuni and C. coli subtypes in housed broiler flocks reared in Great Britain[J]. Appl Environ Microbiol, 2011, 77(11):3741-3748. |
| [19] | WIECZOREK K, OSEK J. Antimicrobial resistance and genotypes of Campylobacter jejuni from pig and cattle carcasses isolated in Poland during 2009-2016[J]. Microb Drug Resist, 2018, 24(5):680-684. |
| [20] | DI GIANNATALE E, CALISTRI P, DI DONATO G, et al. Thermotolerant Campylobacter spp. in chicken and bovine meat in Italy:prevalence,level of contamination and molecular characterization of isolates[J]. PLoS One, 2019, 14(12):e0225957. |
| [21] | OHISHI T, AOKI K, ISHII Y, et al. Molecular epidemiological analysis of human- and chicken-derived isolates of Campylobacter jejuni in Japan using next-generation sequencing[J]. J Infect Chemother, 2017, 23(3):165-172. |
| [22] | OH J Y, KWON Y K, WEI B, et al. Epidemiological relationships of Campylobacter jejuni strains isolated from humans and chickens in South Korea[J]. J Microbiol, 2017, 55(1):13-20. |
| [23] | ZHANG M, GU Y, HE L, et al. Molecular typing and antimicrobial susceptibility profiles of Campylobacter jejuni isolates from north China[J]. J Med Microbiol, 2010, 59(10):1171-1177. |
| [24] | JU C Y, ZHANG M J, MA Y P, et al. Genetic and antibiotic resistance characteristics of Campylobacter jejuni isolated from diarrheal patients,poultry and cattle in Shenzhen[J]. Biomed Environ Sci, 2018, 31(8):579-585. |
| [25] | MA H, SU Y, MA L, et al. Prevalence and characterization of Campylobacter jejuni isolated from retail chicken in Tianjin,China[J]. J Food Prot, 2017, 80(6):1032-1040. |
| [26] | HUR J I, KIM J, RYU S, et al. Phylogenetic association and genetic factors in cold stress tolerance in Campylobacter jejuni[J]. Microbiol Spectr, 2022, 10(6):e0268122. |
| [27] | HUR J I, KIM J, KANG M S, et al. Cold tolerance in Campylobacter jejuni and its impact on food safety[J]. Food Res Int, 2024,175:113683. |
| [28] | LOPES B S, STRACHAN N J C, RAMJEE M, et al. Nationwide stepwise emergence and evolution of multidrug-resistant Campylobacter jejuni sequence type 5136,United Kingdom[J]. Emerg Infect Dis, 2019, 25(7):1320-1329. |
| [29] | 曹健, 刘玥, 王熙, 等. 腹泻患者粪便分离出厄班纳沙门菌ST512型1例[J]. 中华检验医学杂志, 2024, 47(6):698-700. |
| [30] | 韦蓓, 高芬, 刘玥, 等. 从感染者血液分离鉴定胎儿弯曲菌胎儿亚种ST20[J]. 中华检验医学杂志, 2024, 47(9):1102-1105. |
| [31] | 王芳, 高芬, 刘玥, 等. 高毒力高耐药空肠弯曲菌ST7268血流感染确诊1例[J]. 中华检验医学杂志, 2025, 48(1):149-152. |
| [32] | 钟艳, 阮静芳, 覃夏婵, 等. 自职业体检者检出和清除高水平耐药肯塔基沙门菌ST198.2-1[J]. 中华检验医学杂志, 2024, 47(9):1094-1097. |
| [33] | WANG Y, LIU Y, LYU N, et al. The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China[J]. Natl Sci Rev, 2022, 10(3):nwac269. |
| [34] | WANG Y, XU X, ZHU B, et al. Genomic analysis of almost 8 000 Salmonella genomes reveals drivers and landscape of antimicrobial resistance in China[J]. Microbiol Spectr, 2023, 11(6):e0208023. |
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