Serum high mobility group box-1 expression in patients with sepsis caused by bacteria and its clinical significant

doi:10.3969/j.issn.1673-8640.2021.01.016

Abstract

Abstract:

Objective To observe the predictive role of high mobility group box 1 protein（HMGB1）in the survival status of patients with bacterialsepsis. Methods A total of 110 patients with sepsis caused by bacteria confirmed from June 2015 to June 2017were recruited in this study. They were divided into survival group（n=84）and death group（n=26）according to survival status. The plasma level of HMGB1 was measured using ELISA method. The distribution and composition of pathogenic bacteria were analyzed. The relationship between living status and HMGB1 level was investigated. Results HMGB1 leveland APACHEⅡ scorein the survival group were significantly lower than those in the death group were[（36.26±23.57）pg/mL vs（42.67±24.86）pg/mL,16.52±6.35vs26.37±6.74,P<0.05] on the first day after admission.HMGB1 level of the survival group decreased gradually within 7 days after after admission,while HMGB1 level of the death group was unchanged. The higherHMGB1 level,the greaterinfectedrisk of Gram-negative bacteria in sepsis patients. Conclusion HMGB1 can effectively predict the progression of patients with sepsisand evaluate the survival status.

Key words: High mobility group box 1 protein, Sepsis, Bacterial infection, Living status

CLC Number:

R521

FU Jing, TU Xing. Serum high mobility group box-1 expression in patients with sepsis caused by bacteria and its clinical significant[J]. Laboratory Medicine, 2021, 36(1): 80-83.

Figures/Tables 3

References 17

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细菌种类	菌株数/株	构成比/%
革兰阳性菌	44	44
表皮葡萄球菌	14	14
金黄色葡萄球菌	21	21
溶血性葡萄球菌	4	4
腐生葡萄球菌	2	2
肺炎链球菌	3	3
革兰阴性菌	56	56
大肠埃希菌	26	26
鲍曼不动杆菌	9	9
肺炎克雷伯菌	7	7
铜绿假单胞菌	5	5
奇异变形菌	6	6
脑膜炎坏血性黄杆菌	2	2
阴沟肠杆菌	1	1
合计	100	100

细菌种类	菌株数/株	构成比/%
革兰阳性菌	44	44
表皮葡萄球菌	14	14
金黄色葡萄球菌	21	21
溶血性葡萄球菌	4	4
腐生葡萄球菌	2	2
肺炎链球菌	3	3
革兰阴性菌	56	56
大肠埃希菌	26	26
鲍曼不动杆菌	9	9
肺炎克雷伯菌	7	7
铜绿假单胞菌	5	5
奇异变形菌	6	6
脑膜炎坏血性黄杆菌	2	2
阴沟肠杆菌	1	1
合计	100	100

病原菌	例数	HMGB1/（pg/mL）
病原菌	例数	<4.10	4.10~25.60	25.60~34.50	>34.50
革兰阳性菌	48
例数		0	7	30	11
阳性率/%		0.00	14.58	62.50	22.92
革兰阴性菌	62
例数		0	8	16	38
阳性率/%		0.00	12.90	25.81	61.29
χ²值			0.034	16.35	25.37
P值			>0.05	<0.001	<0.001

病原菌	例数	HMGB1/（pg/mL）
病原菌	例数	<4.10	4.10~25.60	25.60~34.50	>34.50
革兰阳性菌	48
例数		0	7	30	11
阳性率/%		0.00	14.58	62.50	22.92
革兰阴性菌	62
例数		0	8	16	38
阳性率/%		0.00	12.90	25.81	61.29
χ²值			0.034	16.35	25.37
P值			>0.05	<0.001	<0.001

组别	HMGB1水平/（pg/mL）				APACHEII评分
组别	第1天	第3天	第5天	第7天	APACHEII评分
生存组	36.26±23.57	32.27±14.85	21.42±13.28	10.87±3.74	16.52±6.35
死亡组	42.67±24.86	39.60±21.34	36.57±18.95	43.87±19.28	26.37±6.74
t值	2.024	2.214	2.527	2.985	2.351
P值	<0.05	<0.05	<0.01	<0.01	<0.05