Research progress on neutrophil to lymphocyte ratio in eye diseases

doi:10.3969/j.issn.1673-8640.2020.05.023

Abstract

Abstract:

Peripheral blood neutrophil to lymphocyte ratio（NLR） is an immune inflammation indicator. Abnormal elevation of NLR indicates poor prognosis of malignant tumors,autoimmune diseases and cardiovascular diseases. Recently,it has been suggested that low-level immune inflammation is probably involved in eye diseases,such as glaucoma,diabetic retinopathy（DR）,macular degeneration and dry eye disease（DED）. Many scholars have explored the relationship between NLR and various eye diseases. In this review,the main clinical application of NLR and its research progress in some eye diseases are summarized.

Key words: Neutrophil to lymphocyte ratio, Eye disease, Biomarker

CLC Number:

R446.1

MA Yingbo, CAO Wenjun. Research progress on neutrophil to lymphocyte ratio in eye diseases[J]. Laboratory Medicine, 2020, 35(5): 501-505.

Figures/Tables 1

References 51

[1]	KRUGER P,SAFFARZADEH M,WEBER A N,et al.Neutrophils:between host defence,immune modulation,and tissue injury[J]. PLoS Pathog,2015,11(3):e1004651.
[2]	PILLAY J,KAMP V M,VAN HOFFEN E,et al.A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1[J]. J Clin Invest,2012,122(1):327-336.
[3]	FARIA S S,FERNANDES P C Jr,SILVA M J,et al. The neutrophil-to-lymphocyte ratio:a narrative review[J]. Ecancermedicalscience,2016,10:702.
[4]	WILLIAMS P A,MARSH-ARMSTRONG N,HOWELL G R,et al.Neuroinflammation in glaucoma:a new opportunity[J]. Exp Eye Res,2017,157:20-27.
[5]	RATAY M L,BELLOTTI E,GOTTARDI R,et al.Modern therapeutic approaches for noninfectious ocular diseases involving inflammation[J]. Adv Healthc Mater,2017,6(23).
[6]	DEHDASHTIAN E,MEHRZADI S,YOUSEFI B,et al.Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin;involvement of autophagy,inflammation and oxidative stress[J]. Life Sci,2018,193:20-33.
[7]	ZENKEL M,LEWCZUK P,JÜNEMANN A,et al. Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome/glaucoma[J]. Am J Pathol,2010,176(6):2868-2879.
[8]	VUJOSEVIC S,SIMÓ R. Local and systemic inflammatory biomarkers of diabetic retinopathy:an integrative approach[J]. Invest Ophthalmol Vis Sci,2017,58(6):BIO68-BIO75.
[9]	REZAR-DREINDL S,SACU S,EIBENBERGER K,et al.The intraocular cytokine profile and therapeutic response in persistent neovascular age-related macular degeneration[J]. Invest Ophthalmol Vis Sci,2016,57(10):4144-4150.
[10]	COUGHLIN B,SCHNABOLK G,JOSEPH K,et al.Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and γδ T-cells[J]. Sci Rep,2016,6:23794.
[11]	SWIERCZAK A,MOUCHEMORE K A,HAMILTON J A,et al.Neutrophils:important contributors to tumor progression and metastasis[J]. Cancer Metastasis Rev,2015,34(4):735-751.
[12]	PROCTOR M J,MCMILLAN D C,MORRISON D S,et al.A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer[J]. Br J Cancer,2012,107(4):695-699.
[13]	马晓路,吴炯,周琰,等. 术前中性粒细胞/淋巴细胞比值对肝细胞肝癌根治性切除术后肿瘤早期复发的影响[J]. 检验医学,2016,31(10):863-868.
[14]	赵卫卫,肖林林,刘秀芬,等. 术前外周血中性粒细胞/淋巴细胞比值在乳腺癌诊断中的作用[J]. 检验医学,2018,33(3):209-212.
[15]	TEMPLETON A J,MCNAMARA M G,ŠERUGA B,et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors:a systematic review and meta-analysis[J]. J Natl Cancer Inst,2014,106(6):dju124.
[16]	ANGKANANARD T,ANOTHAISINTAWEE T,MCEVOY M,et al.Neutrophil lymphocyte ratio and cardiovascular disease risk:a systematic review and meta-analysis[J]. Biomed Res Int,2018,2018:2703518.
[17]	BHAT T,TELI S,RIJAL J,et al.Neutrophil to lymphocyte ratio and cardiovascular diseases:a review[J]. Expert Rev Cardiovasc Ther,2013,11(1):55-59.
[18]	CHANDRASHEKARA S,MUKHTAR AHMAD M,RENUKA P,et al.Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis[J]. Int J Rheum Dis,2017,20(10):1457-1467.
[19]	WU Y,CHEN Y,YANG X,et al.Neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) were associated with disease activity in patients with systemic lupus erythematosus[J]. Int Immunopharmacol,2016,36:94-99.
[20]	戴毅,孙兴怀. 从流行病学角度认识青光眼的特点与危害[J]. 中国眼耳鼻喉科杂志,2016,16(3):179-181.
[21]	LI S,CAO W,HAN J,et al.The diagnostic value of white blood cell,neutrophil,neutrophil-to-lymphocyte ratio,and lymphocyte-to-monocyte ratio in patients with primary angle closure glaucoma[J]. Oncotarget,2017,8(40):68984-68995.
[22]	OZGONUL C,SERTOGLU E,MUMCUOGLU T,et al.Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as novel biomarkers of primary open-angle glaucoma[J]. J Glaucoma,2016,25(10):e815-e820.
[23]	OZGONUL C,SERTOGLU E,MUMCUOGLU T,et al.Prediction of pseudoexfoliation syndrome and pseudoexfoliation glaucoma by using neutrophil to lymphocyte ratio and platelet to lymphocyte ratio[J]. Ocul Immunol Inflamm,2016,24(6):665-670.
[24]	SINGH A,SUBHI Y,KROGH NIELSEN M,et al.Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration:a case-control study[J]. Sci Rep,2017,7(1):605.
[25]	ILHAN N,DAGLIOGLU M C,ILHAN O,et al.Assessment of neutrophil/lymphocyte ratio in patients with age-related macular degeneration[J]. Ocul Immunol Inflamm,2015,23(4):287-290.
[26]	KURTUL B E,OZER P A.The relationship between neutrophil-to-lymphocyte ratio and age-related macular degeneration[J]. Korean J Ophthalmol,2016,30(5):377-381.
[27]	NIAZI S,KROGH NIELSEN M,SØRENSEN T L,et al. Neutrophil-to-lymphocyte ratio in age-related macular degeneration:a systematic review and meta-analysis[J]. Acta Ophthalmol,2019,97(6):558-566.
[28]	SUBHI Y,LYKKE SØRENSEN T. New neovascular age-related macular degeneration is associated with systemic leucocyte activity[J]. Acta Ophthalmol,2017,95(5):472-480.
[29]	SENGUL E A,ARTUNAY O,KOCKAR A,et al.Correlation of neutrophil/lymphocyte and platelet/lymphocyte ratio with visual acuity and macular thickness in age-related macular degeneration[J]. Int J Ophthalmol,2017,10(5):754-759.
[30]	FUJITA T,HEMMI S,KAJIWARA M,et al.Complement-mediated chronic inflammation is associated with diabetic microvascular complication[J]. Diabetes Metab Res Rev,2013,29(3):220-226.
[31]	FAWWAD A,BUTT A M,SIDDIQUI I A,et al.Neutrophil-to-lymphocyte ratio and microvascular complications in subjects with type 2 diabetes:Pakistan's perspective[J]. Turk J Med Sci,2018,48(1):157-161.
[32]	WOO S J,AHN S J,AHN J,et al.Elevated systemic neutrophil count in diabetic retinopathy and diabetes:a hospital-based cross-sectional study of 30 793 Korean subjects[J]. Invest Ophthalmol Vis Sci,2011,52(10):7697-7703.
[33]	LIU J,LIU X,LI Y,et al. The association of neutrophil to lymphocyte ratio,mean platelet volume,and platelet distribution width with diabetic retinopathy and nephropathy:a meta-analysis[J]. Biosci Rep,2018,38(3):BSR20180172.
[34]	LUO W J,ZHANG W F.The relationship of blood cell-associated inflammatory indices and diabetic retinopathy:a Meta-analysis and systematic review[J]. Int J Ophthalmol,2019,12(2):312-323.
[35]	SEKERYAPAN B,UZUN F,BUYUKTARAKCI S,et al.Neutrophil-to-lymphocyte ratio increases in patients with dry eye[J]. Cornea,2016,35(7):983-986.
[36]	CELIK T.Assessment of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with dry eye disease[J]. Ocul Immunol Inflamm,2018,26(8):1219-1222.
[37]	INANC M,TEKIN K,BUDAKOGLU O,et al.Could platelet indices and neutrophil to lymphocyte ratio be new biomarkers for differentiation of arteritic anterior ischemic neuropathy from non-arteritic type?[J]. Neuroophthalmology,2018,42(5):287-294.
[38]	POLAT O,YAVA G F,NAN S,et al.Neutrophil-to-lymphocyte ratio as a marker in patients with non-arteritic anterior ischemic optic neuropathy[J]. Balkan Med J,2015,32(4):382-387.
[39]	DURSUN A,OZTURK S,YUCEL H,et al.Association of neutrophil/lymphocyte ratio and retinal vein occlusion[J]. Eur J Ophthalmol,2015,25(4):343-346.
[40]	TURKSEVEN KUMRAL E,YENEREL N M,ERCALIK N Y,et al.Neutrophil/lymphocyte ratio and mean platelet volume in branch retinal vein occlusion[J]. Saudi J Ophthalmol,2016,30(2):105-108.
[41]	DIKKAYA F,KARAMAN ERDUR S,OZSUTCU M,et al.The significance of neutrophil-to-lymphocyte ratio in idiopathic epiretinal membrane[J]. Int Ophthalmol,2018,38(4):1393-1397.
[42]	ZORENA K,MYLIWSKA J,MYLIWIEC M,et al.Serum TNF-alpha level predicts nonproliferative diabetic retinopathy in children[J]. Mediators Inflamm,2007,2007:92196.
[43]	COSTAGLIOLA C,ROMANO V,DE TOLLIS M,et al.TNF-alpha levels in tears:a novel biomarker to assess the degree of diabetic retinopathy[J]. Mediators Inflamm,2013,2013:629529.
[44]	LECHNER J,CHEN M,HOGG R E,et al.Alterations in circulating immune cells in neovascular age-related macular degeneration[J]. Sci Rep,2015,5:16754.
[45]	PINNA A M,PORCU T M,D'AMICO-RICCI G M,et al. Complete blood cell count-derived inflammation biomarkers in men with age-related macular degeneration[J]. Ocul Immunol Inflamm,2019,27(6):932-936.
[46]	ULU S M,DOGAN M,AHSEN A,et al.Neutrophil-to-lymphocyte ratio as a quick and reliable predictive marker to diagnose the severity of diabetic retinopathy[J]. Diabetes Technol Ther,2013,15(11):942-947.
[47]	ÖZTÜRK Z A,KUYUMCU M E,YESIL Y,et al. Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients?[J]. J Endocrinol Investi,2013,36(8):593-599.
[48]	WANG R T,ZHANG J R,LI Y,et al.Neutrophil-lymphocyte ratio is associated with arterial stiffness in diabetic retinopathy in type 2 diabetes[J]. J Diabetes Complications,2015,29(2):245-249.
[49]	CIRAY H,AKSOY A H,ULU N,et al.Nephropathy,but not angiographically proven retinopathy,is associated with neutrophil to lymphocyte ratio in patients with type 2 diabetes[J]. Exp Clin Endocrinol Diabetes,2015,123(5):267-271.
[50]	YUE S,ZHANG J,WU J,et al.Use of the monocyte-to-lymphocyte ratio to predict diabetic retinopathy[J]. Int J Environ Res Public Health,2015,12(8):10009-10019.
[51]	DIKKAYA F,KARAMAN ERDUR S,OZSUTCU M,et al.The significance of neutrophil-to-lymphocyte ratio in idiopathic epiretinal membrane[J]. Int Ophthalmol,2018,38(4):1393-1397.